Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A
Figure 3
Comparison of carboxypeptidase-bound structures. (a) CPA in complex with BzlSA (PDB entry 1cbx). (b) CPA with bound citrate (this work). BzlSA and citrate are shown magenta and green, respectively. Ala250 and Ile255, enclosing the ligand, are in orange. Note the location of two water molecules (spheres in red) at (b), masking hydrophobic residues at the bottom of the active site. Hydrogen bond interactions are as dashed lines in black. Both structures are shown in similar orientation.
