The Role of Manganese Superoxide Dismutase in Inflammation Defense

Figure 2

The three-dimensional (3D) structure of human manganese superoxide dismutase (a) and that of the synthetic superoxide dismutase mimetic M40403 (b). The 3D structure of M40403 and the active site of MnSOD (c). This manganese-containing biscyclohexylpyridine has superior catalytic activity compared to that of the native enzyme. Note that Mn²⁺ is purple and Cl⁻ is light green in the 3D structure of M40403.

(a)

(b)

(c)