Singular Features of Trypanosomatids' Phosphotransferases Involved in Cell Energy Management

Table 1

Characteristics of trypanosomatids’ phosphotransferases. Summary of the main features of arginine kinases (AKs), adenylate kinases (ADKs), and nucleoside diphosphate kinases (NDPKs) isoforms from trypanosomatids. Predicted subcellular localizations are indicated with a question mark. The existence or not of human equivalents (human), N- or C-terminal extensions (N-t and C-t), peroxisomal targeting signal (PTS-1), and DM10 motifs are also detailed.

Enzyme	Organism	Isoform	Localization	Human	Features
AK	T. cruzi/T.brucei	1	Cytosol	No	Canonical
	T. brucei	2	?	No	N-t
		3	?	No	C-t
ADK	T. cruzi/T. brucei/L. major	1	Flagellum	Yes	N-t
		2	Reservosome (?)	Yes	—
		3	Glycosome	Yes	PTS-1
		4	Flagellum	Yes	N-t
		5	Cytosol	Yes	Canonical
		6	Mitochondria	Yes	—
	T. brucei	7 (A)	Flagellum	Yes	N-t
NDPK	T. cruzi/T. brucei/L. major	1	Nucleus (?)	Yes	Canonical
		2	Cytoskeleton	Yes	DM10
		3	?	Yes	DM10
	T. cruzi/T. brucei	4	?	Yes	Putative