Interaction between Calcineurin and Ca2+/Calmodulin Kinase-II in Modulating Cellular Functions
Figure 2
A simplified model of the involvement of CaN and CaMKII in the modulation of K+ channel activity and Ca2+-release channels in intracellular Ca2+-stores in renal tubule cells. Circled “+” and “−” indicate stimulation and inhibition, respectively. Actions of CyA on Ca2+-release channel and CaMKII are also shown. Ca2+ released from the Ca2+-store may further enhance the activity of CaMKII, as shown by the dotted line.
