The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease

Figure 3

Comparison of the CWH43 proteins from fungi and Tritryps. The amino acid sequences of CWH43 proteins from Aspergillus fumigatus (ASPFU), Emericella nidulans (EMENI), Saccharomyces cerevisiae (YEAST) and Schizosaccharomyces pombe (SCHPO) were compared with the putative CWH43p candidates from Leishmania major (LEIMA), Leishmania infantum (LEIIN) and Trypanosoma cruzi (TRYCR). Thick horizontal bars indicate the relative positions of the membrane-spanning domains as predicted by the TMHMM Server. Dashed lines delineate the relative positions of the FRAG1 and DNase I-like domains, which are located at the N- and C-terminus, respectively.