Enolase: A Key Player in the Metabolism and a Probable Virulence Factor of Trypanosomatid Parasites—Perspectives for Its Use as a Therapeutic Target
Figure 1
Characteristics of the enolase sequences of trypanosomatids. Alignment of the amino-acid sequences of enolase from L. mexicana (accession number ABA64522), T. brucei (accession number XP_822542), T. cruzi (accession number XP_819700), human α-enolase (accession number NP_001419), and S. pneumoniae (accession number Q97QS2). Open circles indicate residues involved in ligand binding (PEP, metals), closed circles unique reactive active-site residues found in enolases of trypanosomatids. The bar indicates the plasminogen-binding motif in S. pneumoniae. This plasminogen-binding peptide contains both positively and negatively charged residues flanked by hydrophobic amino acids, important for plasminogen binding [31].
