A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C

Figure 1

Superposition of GH30 family member structures. Cartoon representation: apo GCase (PDB code 3GXD), raspberry red; xylanases, yellow (PDB code 1NOF) and blue (PDB code 3LK0); SrfJ, green (pdb code 2WNW). (a) Overall structures with domains labeled. Arrows 1, 2: deviations in Domains 1 and 2, respectively (see text). (b) Top: comparison of GCase and xylanases (blue, yellow) in Domain 1 region; bottom: comparison of GCase and SrfJ (green) in Domain 1 region. (c) Active site region (Domain 2) with select amino acid side chains depicted in ball-and-stick.