A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C

Figure 9

Structures of SapC. (a) Overlay of structures presented in (b)–(f) colored in a rainbow from N-terminus (blue) to C-terminus (red). (b) Closed NMR structure (PDB code 1M12). (c) Closed crystal structure (PDB code 2GTG). (c) Open NMR structure (PDB code 1SN6). (d) Open crystallographic dimer (orthorhombic, PDB code 2Z9A). (e) Open crystallographic dimer (tetragonal, PDB code 2QYP).

(a)

(b)

(c)

(d)

(e)

(f)