Research Article
Chiral Pharmaceutical Intermediaries Obtained by Reduction of 2-Halo-1-(4-substituted phenyl)-ethanones Mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182
Table 1
Asymmetric reduction of 2-halo-1-(4-substituted phenyl)-ethanones 1a-j mediated by Geotrichum candidum CCT 1205 and Rhodotorula glutinis CCT 2182a.
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a18 h, 2 mmol of ketone/1.5 mL of EtOH was added to 15 g of yeast (wet weight)/400 mL of nutrient broth 1 (malt extract, peptone) for Geotrichum candidum or nutrient broth 2 (yeast extract, malt extract, peptone) for Rhodotorula glutinis. bee>99%. cSee Materials and Methods for c values and solvent. |