Brain Levels of Catalase Remain Constant through Strain, Developmental, and Chronic Alcohol Challenges
Figure 3
Within strain comparisons show no difference between control and ethanol-fed rats. Age-matched rats of the Long-Evans (LE) and Sprague-Dawley (SD) strains were pair-fed control or ethanol-containing diets for three weeks starting either as: (1) preadolescents at postnatal age 25–28 days (P25–28) ending treatment at P46–49 or as (2) adults (P75 or greater) ending treatment at P96 or greater. Rats were sacrificed at the end of the treatment period, and the brains were dissected for determination of catalase activity in synaptosomal fractions solubilized with 0.1% sodium deoxycholate. The age for each treatment group pair at the time of analysis is shown. Catalase activity is expressed as mol H2O2 min−1·mg protein−1 and presented as . For each treatment group pair, there was no significant difference in synaptosomal catalase activity.
