Estimation of Inhibitory Effect against Tyrosinase Activity through Homology Modeling and Molecular Docking

Figure 1

Sequence alignment between human amino acid sequence (AAA61242) and crystal structure of bacterial tyrosinase (3NQ1) with identity of 33.5% and similarity of 50.7%. Six histidine residues, which are provided by a four-helical bundle, coordinate the two copper ions (CuA and CuB) in the active site [1].