Table 2: IC50 values (±SEM) for vorozole and letrozole on CYP1A1, CYP1A2, CYP2A6, CYP3A4, and CYP19A1 for 3 replicate assays.

Vorozole (M)Letrozole (M)Fold difference

CYP1A10.469 ± 0.031 69.8 ± 5.3149
CYP1A2321 ± 49332 ± 1951.03
CYP2A624.4 ± 3.6106 ± 34 4.34
CYP3A498.1 ± 15.6<10% @ 1 mM>10
CYP19A10.00417 ± 0.00019 0.00727 ± 0.000701.73