Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase: Alcohol Use and Type 2 Diabetes in Japanese Men
Table 2
Association of ADH1B and ALDH2 polymorphisms with prediabetic condition and type 2 diabetes.
Genotype
Prediabetic condition*
Type 2 diabetes
No. of Controls
No.
Crude OR (95% CI)
Adjusted OR (95% CI)†
No.
Crude OR (95% CI)
Adjusted OR (95% CI)†
ADH1B Arg47His
His/His
851
310
1.00 (referent)
1.00 (referent)
131
1.00 (referent)
1.00 (referent)
Arg/His
558
204
1.00 (0.82–1.23)
0.97 (0.78–1.20)
88
1.02 (0.77–1.37)
1.00 (0.74–1.35)
Arg/Arg
97
35
0.99 (0.66–1.49)
0.89 (0.59–1.36)
13
0.87 (0.47–1.60)
0.81 (0.43–1.52)
Arg/His + Arg/Arg
655
239
1.00 (0.82–1.22)
0.96 (0.78–1.18)
101
1.00 (0.76–1.32)
0.97 (0.73–1.30)
ALDH2 Glu487Lys
Glu/Glu
871
368
1.00 (referent)
1.00 (referent)
172
1.00 (referent)
1.00 (referent)
Glu/Lys
553
161
0.69 (0.56–0.85)
0.79 (0.63–1.01)
61
0.56 (0.41–0.76)
0.54 (0.38–0.77)
Lys/Lys
92
23
0.59 (0.37–0.95)
0.83 (0.48–1.43)
2
0.11 (0.03–0.45)
0.12 (0.03–0.52)
Glu/Lys + Lys/Lys
645
184
0.68 (0.55–0.83)
0.80 (0.63–1.01)
63
0.49 (0.36–0.67)
0.51 (0.36–0.72)
CI: confidence interval; OR: odd ratio. Impaired fasting glucose and impaired glucose tolerance were combined. Adjusted for age, hospital, rank in the Self Defense Forces, body mass index, smoking, alcohol use, coffee intake, leisure-time physical activity, and parental diabetes mellitus.
