Genetic Polymorphisms of Alcohol Dehydrogenase and Aldehyde Dehydrogenase: Alcohol Use and Type 2 Diabetes in Japanese Men

Table 6

Interaction between alcohol use and ALDH2 Glu487Lys polymorphism in relation to prediabetic condition and type 2 diabetes.

ALDH2 Genotype			Alcohol intake (mL/day)			Trend
		Never use	<30	30–59	≥60
Prediabetic condition
Glu/Glu	No.*	11/32	70/199	133/322	149/296
	OR (95% CI)^†	1:00 (referent)	1.11 (0.52–2.37)	1.25 (0.60–2.62)	1.56 (0.75–3.27)	𝑃=.07
Glu/Lys	No.*	30/138	64/192	44/124	18/83
	OR (95% CI)^†	0.66 (0.29–1.49)	1.07 (0.50–2.30)	1.19 (0.54–2.62)	0.73 (0.30–1.76)	𝑃=.37
Difference		𝑃=.47	𝑃=.95	𝑃=.79	𝑃=.009
		Interaction 𝑃=.42
Type 2 diabetes
Glu/Glu	No.*	6/32	45/199	58/322	57/296
	OR (95% CI)^†	1:00 (referent)	0.98 (0.37–2.56)	0.73 (0.28–1.87)	0.78 (0.30–2.02)	𝑃=.29
Glu/Lys	No.*	14/138	25/192	12/124	7/83
	OR (95% CI)^†	0.40 (0.14–1.15)	0.59 (0.22–1.60)	0.42 (0.14–1.24)	0.35 (0.10–1.15)	𝑃=.59
Difference		𝑃=.09	𝑃=.08	𝑃=.13	𝑃=.03
		Interaction 𝑃=.83

CI: interval confidence; OR: odd ratio.
∗Numbers of cases/controls.
†Adjusted for age, hospital, rank in the Self Defense Forces, body mass index, smoking, coffee intake, leisure–time physical activity, and parental diabetes mellitus.