Table of Contents
Epidemiology Research International
Volume 2012 (2012), Article ID 138259, 7 pages
http://dx.doi.org/10.1155/2012/138259
Clinical Study

Trypanosoma cruzi Infection in an Indigenous Kariña Community in Eastern Venezuela

1Postgrado en Biología Aplicada, Núcleo de Sucre, Universidad de Oriente, Cumaná, Estado Sucre 6101, Venezuela
2Instituto de Investigaciones en Biomedicina y Ciencias Aplicadas, Universidad de Oriente, Cumaná, Estado Sucre 6101, Venezuela
3Departamento de Bioanálisis, Núcleo de Sucre, Universidad de Oriente, Cumaná, Estado Sucre 6101, Venezuela
4National Reference Centre for Parasitology, Research Institute of the McGill University Health Centre (MUHC), Department of Medicine, Montreal General Hospital, 1650 Cedar Avenue, Room R3-R137, Montreal, QC, Canada H3G 1A4
5Centro de Investigaciones en Ciencias de la Salud, Núcleo de Anzoátegui, Universidad de Oriente, Barcelona, Estado Anzoátegui 6001, Venezuela
6Gerencia de Saneamiento Ambiental y Control de Endemias, Ministerio del Poder Popular para la Salud, Fundasalud Sucre, Carúpano, Estado Sucre 6150, Venezuela

Received 6 March 2012; Revised 7 August 2012; Accepted 23 August 2012

Academic Editor: Percy Mayta-Tristán

Copyright © 2012 Mariolga Berrizbeitia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We investigated the seroprevalence of Trypanosoma cruzi infection in an indigenous Kariña population in eastern Venezuela. A total of 175 serum samples were collected in the community of Piñantal during February 2009. Interviews targeting socioeconomic and environmental factors associated with the T. cruzi transmission were also conducted. Samples were evaluated using trypomastigote excreted/secreted antigens (TESAs) in an ELISA format. TESA-ELISA positive samples were confirmed by indirect haemagglutination (HAI) (Wiener). A nonsystematic collection of vectors was also undertaken. T. cruzi seroprevalence was 7.43% according to both assays, and the mean age of infected patients was years (range 34 to 73 years). The vector infection rate was 20.00% (2/10). T. cruzi seropositivity was associated with a history of triatomine bites, the ability to recognize the vector and poor knowledge about Chagas disease, but no associations were found with gender, house type, knowledge of how the disease is transmitted, or the presence of vectors or animals inside dwellings. To our knowledge, this is the first study of the seroprevalence of T. cruzi in an indigenous population in eastern Venezuela. All of the epidemiological variables required for the establishment of active vectorial transmission of T. cruzi were present in this community.