The Time of the Insult/Triggering Event in Primary Osteosarcoma and Ewing’s Sarcoma of Bone as Determined by Incubation Period Modeling and Age Distribution of Such Malignancies

Table 4

Demographics of osteosarcoma and Ewing’s sarcoma from the literature.

Study	Year	Time span	Location		M	F	% M	W	B	Hispanic	Asian	% W	% B
Osteosarcoma
Present study	—	1993–2010	USA	4594	2535	2059	55.2	3508	663	41	273	77.1	14.4
Bovill Jr. et al. [23]	1975	1969–1972	Malaysia	68	40	28	58.8
Young Jr. and Miller [24]	1975	1969–1972	USA	61	32	29	52.5	51	10			83.6	16.4
Buckley et al. [25]	1998	1982-1983	USA/Canada	152	75	77	49.3	127	15	10	0	83.6	9.9
Jensen and Drake [26]	1970	1940–1968	USA (AFIP)	677				595	82			87.9	12.1
Fraumeni Jr. and Glass [27]	1970	1960–1966	USA	819	452	367	55.2	692				84.5	—
Bassin et al. [28]	2006	1989–1992	USA	103	60	43	58.3	81	16		3	78.6	15.5
Finkelstein [29]	1994	1950–1983	Ontario, Canada	20	15	5	75.0
Operskalski et al. [30]	1987	1972–1982	Los Angeles, CA	64	34	30	53.1	43	13	8		67.2	20.3
Eyre et al. [31]	2009	1981–2002	Northern England and West Midlands	206	95	111	46.1	—	—	—	—	—	—
Stiller et al. [32]	1991	1981–1990	UK	150				130			7	86.7	0.0
Stiller et al. [33]	2006	1978–1997	Europe	1609	889	720	55.3						0.0
Cotterill et al. [34]	2000	1968–1995	Northern England	131	77	54	58.8	—	—	—	—	—	—
Ewing’s Sarcoma
Present study	—	1993–2010	USA	2321	1420	90	61.2	2098	70	22	75	90.4	3.0
Young Jr. and Miller[24]	1975	1969–1972	USA	26	15	11	57.7						—
Buckley et al. [25]	1998	1982-1983	USA/Canada	153	89	64	58.2	139	1	10	3	90.8	0.7
Jensen and Drake [26]	1970	1940–1968	USA (AFIP)	239				237	2			99.2	0.8
Fraumeni Jr. and Glass [27]	1970	1960–1966	USA	482	265	217	55.0	456	—	—	—	94.6	—
Linden and Dunn [35]	1970	—	California, USA	149				147	2			98.7	1.3
Finkelstein [29]	1994	1950–1983	Ontario, CA	15	9	6	60.0
Moore et al. [36]	2005	1983–1985	USA	196	120	76	61.2	184				93.9	0.0
Holly et al. [37]	1992	1978–1986	San Francisco, CA	43	28	15	65.1					0.0	—
Eyre et al. [31]	2009	1981–2002	Northern England and West Midlands	144	74	70	51.4					0.0	—
Stiller et al. [32]	1991	1981–1990	UK	172			0.0	156			8	90.7	—
Stiller [33]	2006	1978–1997	Europe	1182	647	535	54.7	—	—	—	—		—
Cotterill et al. [34]	2000	1968–1995	Northern England	81	53	28	65.4	—	—	—	—		—