Connexin36 Gap Junction Blockade Is Ineffective at Reducing Seizure-Like Event Activity in Neocortical Mouse Slices

Table 2

Change in seizure-like event amplitude, frequency, and length (% change) for the three groups after 60 minutes of aconitine perfusion. Data are median (95% confidence interval).

	WT; (𝑛=12, 3 animals)	WT + mefloquine; (𝑛=12, 3 animals)	Cx36 KO; (𝑛=14, 3 animals)	P value
Amplitude (% change)	−37 (−54–−26)	−48 (−64–−25)	−49 (−61–5)	.76
Length (% change)	−28 (−50–1)	−37 (−61–−27)	−46 (−66–9)	.50
Frequency (% change)	900 (657–1272)	557 (322–737)	640 (416–1284)	.13

WT: wild-type.
Cx36 KO, connexin36 knockout.
P-values from Kruskal-Wallis test (nonparametric ANOVA) comparing the % change across all three groups.