Table of Contents
Epilepsy Research and Treatment
Volume 2011, Article ID 369295, 8 pages
Review Article

Neuroimaging in Animal Seizure Models with 18FDG-PET

1Department of Pharmacological Sciences, Molecular and Cellular Pharmacology, Stony Brook University, Stony Brook, NY 11794-8651, USA
2Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
3Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA

Received 13 October 2010; Revised 24 February 2011; Accepted 31 March 2011

Academic Editor: Helen E. Scharfman

Copyright © 2011 Martine M. Mirrione and Stella E. Tsirka. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Small animal neuroimaging has become increasingly available to researchers, expanding the breadth of questions studied with these methods. Applying these noninvasive techniques to the open questions underlying epileptogenesis is no exception. A major advantage of small animal neuroimaging is its translational appeal. Studies can be well controlled and manipulated, examining the living brain in the animal before, during, and after the disease onset or disease treatment. The results can also be compared to data collected on human patients. Over the past decade, we and others have explored metabolic patterns in animal models of epilepsy to gain insight into the circuitry underlying development of the disease. In this paper, we provide technical details on how metabolic imaging that uses 2-deoxy-2[18F]fluoro-D-glucose (18FDG) and positron emission tomography (PET) is performed and explain the strengths and limitations of these studies. We will also highlight recent advances toward understanding epileptogenesis through small animal imaging.