Characterization of the Gene Expression Profile of Human Hippocampus in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Table 1

Clinical history, MRI findings, pathological diagnosis, and postoperative outcome of 10 patients who underwent selective amygdalohippocampectomy.

Case no.	Age/sex	MRI findings	Pathological diagnosis of hippocampus	AED medication	Type of seizures	Years with epilepsy	No. seizures/month
1^a, b, c	21/M	MTS, left	mild gliosis, focal neuronal loss	LTG, LEV	SPS, CPS	19	30
2 ^a, b, c	26/F	MTS, right	mild gliosis, severe neuronal loss	CBZ, GP, LEV	CPS, SGS	10	8
3 ^a, b, c	28/F	MTS, left	marked gliosis, severe neuronal loss (Wyler II)^f	OXC, LTG, PHT	SPS, CPS, SGS	26	2
4 ^a, b, c	27/M	MTS, right	marked gliosis, severe neuronal loss (Wyler II)	LTG, LEV	CPS, SGS	25	4
5 ^a, b, c	34/F	MTS, left	marked gliosis, severe neuronal loss (Wyler III)	LEV, PB	SPS, CPS, SGS	32	6
6 ^b, c	40/F	MTS, left	marked gliosis, focal mild neuronal loss	VPA, LEV	CPS, SGS	18	12
7 ^b, c	68/F	MTS, right	marked gliosis, severe neuronal loss	LTG, LEV	SPS, CPS	43	4
8 ^b, c	22/M	MTS, right	marked gliosis, severe neuronal loss (Wyler IV)	CBZ, GP, LEV	SPS, CPS, SGS	18	4
9 ^d, e	41/M	MTS, right	marked gliosis, severe neuronal loss (Wyler IV)	CBZ, VPA, TPM	SPS, CPS, SGS	6	2
10 ^d, e	41/F	MTS, left	marked gliosis, severe neuronal loss	CBZ, LEV, PHT	SPS, CPS, SGS	20	2

AEDs: antiepileptic drugs; CBZ: carbamazepine; LEV: levetiracetam; LTG: lamotrigine; PHT: phenytoin; TPM: topiramate; GP: gabapentin; PB: phenobarbital; OXC: oxcarbazepine; VPA: valproic acid.
SPS: simple partial seizures; CPS: complex partial seizures; SGS: secondary generalized seizures.
^aImmunohistochemistry.
^bOne-cycle target labelling gene array.
^cQuantitative real-time RT-PCR (TaqMan).
^dBrain-derived microvascular endothelial cells (MVECs).
^eTwo-cycle target labeling gene array.
^fWyler classification was not determined in all cases.
MTS, mesial temporal sclerosis.