Characterization of the Gene Expression Profile of Human Hippocampus in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis

Table 2

Averaged relative gene expression values of AHE, MVEC, and control of the ATP-binding cassette (ABCB1, ABCB2, ABCB3, and ABCC4).

Genes	Symbol	Control^a	AHE^a	MVEC^a
ATP-binding cassette, sub-family B (MDR/TAP), member 1	ABCB1/P-gp	1 ± 0.03	0.91 ± 0.24	37.22 ± 0.97 (𝑃=.0003)^b
Transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	ABCB2/TAP1	1 ± 0.19	1.13 ± 0.33	21.08 ± 2.82 (𝑃=.0017)
Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)	ABCB3/TAP2	1 ± 0.11	1.14 ± 0.27	13.39 ± 6.08 (𝑃=.0012)
ATP-binding cassette, sub-family C (CFTR/MRP), member 4	ABCC4/MRP4	1 ± 0.07	2.13 ± 0.68 (𝑃=.001)	5.39 ± 2.44) (𝑃=.005)

^aFold changes were calculated on the bases of normalized values calculated by Genespring 5.0. The mean values of the three controls were set to the value of 1. The data are presented as a mean ± SD.
^bThe statistical differences in comparison to control are indicated (𝑃-value, Student’s t-Test).