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Epilepsy Research and Treatment
Volume 2012 (2012), Article ID 198183, 8 pages
Review Article

Functional Magnetic Resonance Imaging for Language Mapping in Temporal Lobe Epilepsy

1Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada N6A 5K8
2Department of Medical Biophysics, Western University, London, ON, Canada N6A 5C1
3Department of Medical Imaging, Western University, London, ON, Canada N6A 5A5
4Biomedical Engineering Program, Western University, London, ON, Canada N6A 5B9
5Department of Clinical Neurological Science, Western University, London, ON, Canada N6A 5A5
6Department of Psychology, Western University, London, ON, Canada N6A 5A5

Received 2 February 2012; Accepted 28 June 2012

Academic Editor: Warren T. Blume

Copyright © 2012 An Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Functional magnetic resonance imaging (fMRI) is a noninvasive technique that is increasingly used to understand the cerebral cortical networks and organizations. In this paper, we describe the role of fMRI for mapping language networks in the presurgical workup of patients with medically intractable temporal lobe epilepsy (TLE). Studies comparing fMRI with the intracarotid sodium amobarbital (Wada) test and fMRI with intraoperative cortical stimulation mapping for language lateralization and/or localization in medically intractable TLE are discussed.