Table of Contents
Epilepsy Research and Treatment
Volume 2012, Article ID 209701, 6 pages
Review Article

Temporal Lobe Epilepsy after Refractory Status Epilepticus: An Illustrative Case and Review of the Literature

1Division of Critical Care Medicine, Kingston General Hospital, Queen’s University, Kingston, ON, Canada K7L 2V7
2Department of Clinical Neurological Sciences, London Health Sciences Centre, London, ON, Canada N6A 5A5

Received 4 October 2011; Accepted 29 January 2012

Academic Editor: Seyed M. Mirsattari

Copyright © 2012 J. Gordon Boyd et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


New onset refractory status epilepticus (NORSE) is a relatively newly defined disease entity, where otherwise healthy individuals develop unrelenting seizures that do not respond to conventional anticonvulsant therapy and may require months of therapy with anesthetic drugs. We have described a case of NORSE who subsequently developed mesial temporal lobe sclerosis (MTS) and recurrent temporal lobe seizures. We discuss the possible pathophysiological mechanisms by which refractory seizures may contribute to the development of temporal lobe epilepsy (TLE).