Table of Contents
Epilepsy Research and Treatment
Volume 2012, Article ID 370351, 5 pages
Research Article

Postoperative Neuropsychological Outcome in Patients with Mesial Temporal Lobe Epilepsy in Argentina

1Epilepsy Center, Neurology Division, Ramos Mejia Hospital, Urquiza 609, Buenos Aires, PC C1221ADC, Argentina
2Neuroscience and Cellular Biology Institute “Prof. Dr. Eduardo De Robertis”, Medicine Faculty, Buenos Aires University, Paraguay 2155, Buenos Aires City, PC C1121ABG, Argentina
3Research Center of Pharmacobiology and Botanic, CEFYBO, Buenos Aires University, Paraguay 2155, Buenos Aires City, PC C1121ABG, Argentina
4National Council of Scientific and Technology Research (CONICET), Buenos Aires, Argentina

Received 11 April 2011; Revised 10 August 2011; Accepted 8 October 2011

Academic Editor: Seyed M. Mirsattari

Copyright © 2012 Silvia Oddo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of the present study is to compare pre- and postsurgical neuropsychological outcome in individuals suffering from mesial temporal lobe epilepsy (mTLE), in order to evaluate prognosis. The selected thirty-five patients had medically mTLE and had undergone an anterior temporal lobectomy (ATL). Neuropsychological evaluation was performed in three different stages: before ATL, 6 months after resection, and a year afterwards. Neuropsychological protocol evaluated attention, verbal memory, visual memory, executive function, language, intelligence, and handedness. There was a significant improvement ( 𝑃 = 0 . 0 3 0 ) in the group with visual memory deficit after surgery, whereas no changes were observed across patients with verbal memory deficit. No changes were observed in language after surgery. Executive function showed significant improvement 6 months after surgery ( 𝑃 = 0 . 0 3 5 ). Postoperative outcome of cognitive impairments depends on baseline neuropsychological status of the patients with TLE. In our case series, deficits found in patients with mTLE after ATL did not result in a subjective complaint.