Table 2: Seizure prevalence in psychiatric samples during treatment with antidepressant drugs [36].

AntidepressantDosage (mg)Seizure prevalence (%)

Tricyclic Antidepressants (TCA’s)
Amitriptyline<200 mg0.1
>200 mg0.6
Imipramine50–600 mg<0.1–0.9
Clomipramine>200 mg0.5
Tetracyclic Antidepressants
Maprotiline150–200 mg0.4
Mirtazepine30 mg<0.1
Selective Serotonin Reuptake Inhibitors (SSRI’s)
Fluoxetine20–60 mg0.2
Fluvoxamine<100 mg0.2
Sertraline50–100 mg<0.1
Paroxetine20–60 mg0.1
Norepinephrine Dopamine Reuptake Inhibitor (NDRI’s)
300 mg SR0.1
Bupropion300–450 mg IR0.4
>450 mg IR>0.6