Review Article
Depression in Temporal Lobe Epilepsy: A Review of Prevalence, Clinical Features, and Management Considerations
Table 3
CYP450 enzymes inhibition and induction by antidepressants and antiepileptic drugs [
36].
| CYP isoenzyme | Inhibitors | Inducers | Substrates |
| CYP 1A2 | Fluvoxamine | St. John’s Wort | Antidepressants | | Fluoxetine | | TCA’s | | Paroxetine | | Fluvoxamine | | Tertiary TCA’s | | Mirtazepine | | | | Duloxetine |
| CYP 2C9/10 | Fluoxetine | Phenobarbital | Antidepressants | | Fluvoxamine | Carbamazepine | Sertraline | | | Phenytoin | Fluoxetine | | | | Amitriptyline | | | | Bupropion | | | | Antiepileptics | | | | Phenytoin |
| CYP 2C19 | Fluvoxamine | Carbamazepine | Antidepressants | | Fluoxetine | Phenytoin | Citalopram | | | | Escitalopram | | | | Sertraline | | | | Clomipramine | | | | Imipramine | | | | Moclobemide | | | | Antiepileptics | | | | Phenytoin | | | | Mephenytoin | | | | Esobarbital | | | | Mephobarbital | | | | Phenobarbital | | | | Primidone |
| CYP 2D6 | Fluoxetine | | Antidepressants | | Paroxetine | | Fluoxetine | | Sertraline | | Fluvoxamine | | Secondary TCA’s | | Citalopram | | | | Escitalopram | | | | Duloxetine | | | | Paroxetine | | | | Venlafaxine | | | | Trazodone | | | | Maprotiline | | | | Mirtazepine | | | | TCA’s |
| CYP 3A4 | Fluoxetine | Carbamazepine | Antidepressants | | Fluvoxamine | Barbiturates | Sertraline | | Mirtazepine | Phenytoin | Venlafaxine | | | St. John’s Wort | Escitalopram | | | | Mirtazepine | | | | Trazodone | | | | TCA’s | | | | Antiepileptics | | | | Carbamazepine | | | | Zonisamide | | | | Tigabine |
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