Table of Contents
Epilepsy Research and Treatment
Volume 2012 (2012), Article ID 849540, 16 pages
http://dx.doi.org/10.1155/2012/849540
Review Article

Temporal Lobe Epilepsy in Children

1Divisions of Epilepsy and Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
2Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA

Received 10 June 2011; Accepted 21 August 2011

Academic Editor: Seyed M. Mirsattari

Copyright © 2012 Katherine C. Nickels et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. C. Wirrell, B. R. Grossardt, L. C. L. Wong-Kisiel, and K. C. Nickels, “Incidence and classification of new-onset epilepsy and epilepsy syndromes in children in Olmsted county, Minnesota from 1980 to 2004: a population-based study,” Epilepsy Research, vol. 95, no. 1-2, pp. 110–118, 2011. View at Publisher · View at Google Scholar
  2. C. S. Camfield, P. R. Camfield, K. Gordon, E. Wirrell, and J. M. Dooley, “Incidence of epilepsy in childhood and adolescence: a population-based study in Nova Scotia from 1977 to 1985,” Epilepsia, vol. 37, no. 1, pp. 19–23, 1996. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Adelöw, E. Åndell, P. Åmark et al., “Newly diagnosed single unprovoked seizures and epilepsy in Stockholm, Sweden: first report from the Stockholm incidence registry of epilepsy (SIRE),” Epilepsia, vol. 50, no. 5, pp. 1094–1101, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Blom, J. Heijbel, and P. G. Bergfors, “Incidence of epilepsy in children: a follow-up study three years after the first seizure,” Epilepsia, vol. 19, no. 4, pp. 343–350, 1978. View at Google Scholar · View at Scopus
  5. J. Christensen, M. Vestergaard, M. G. Pedersen, C. B. Pedersen, J. Olsen, and P. Sidenius, “Incidence and prevalence of epilepsy in Denmark,” Epilepsy Research, vol. 76, no. 1, pp. 60–65, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Doose and B. Sitepu, “Childhood epilepsy in a German city,” Neuropediatrics, vol. 14, no. 4, pp. 220–224, 1983. View at Google Scholar · View at Scopus
  7. A. Simon Harvey, S. F. Berkovic, J. A. Wrennall, and L. J. Hopkins, “Temporal lobe epilepsy in childhood: clinical, EEG, and neuroimaging findings and syndrome classification in a cohort with new-onset seizures,” Neurology, vol. 49, no. 4, pp. 960–968, 1997. View at Google Scholar · View at Scopus
  8. G. D. Cascino, “Surgical treatment for epilepsy,” Epilepsy Research, vol. 60, pp. 179–186, 2004. View at Google Scholar
  9. A. Ray and P. Kotagal, “Temporal lobe epilepsy in children: overview of clinical semiology,” Epileptic Disorders, vol. 7, no. 4, pp. 299–307, 2005. View at Google Scholar · View at Scopus
  10. A. Fogarasi, I. Tuxhorn, J. Janszky et al., “Age-dependent seizure semiology in temporal lobe epilepsy,” Epilepsia, vol. 48, no. 9, pp. 1697–1702, 2007. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Fogarasi, H. Jokeit, E. Faveret, J. Janszky, and I. Tuxhorn, “The effect of age on seizure semiology in childhood temporal lobe epilepsy,” Epilepsia, vol. 43, no. 6, pp. 638–643, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. B. F. Bourgeois, “Temporal lobe epilepsy in infants and children,” Brain and Development, vol. 20, no. 3, pp. 135–141, 1998. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Brockhaus and C. E. Elger, “Complex partial seizures of temporal lobe origin in children of different age groups,” Epilepsia, vol. 36, no. 12, pp. 1173–1181, 1995. View at Publisher · View at Google Scholar · View at Scopus
  14. V. C. Terra-Bustamante, L. M. Inuzuca, R. M. Fernandes et al., “Temporal lobe epilepsy surgery in children and adolescents: clinical characteristics and post-surgical outcome,” Seizure, vol. 14, no. 4, pp. 274–281, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Bocti, Y. Robitaille, P. Diadori et al., “The pathological basis of temporal lobe epilepsy in childhood,” Neurology, vol. 60, no. 2, pp. 191–195, 2003. View at Google Scholar · View at Scopus
  16. E. A. Cavalheiro, D. F. Silva, W. A. Turski, L. S. Calderazzo-Filho, Z. A. Bortolotto, and L. Turski, “The susceptibility of rats to pilocarpine-induced seizures is age-dependent,” Brain Research, vol. 465, no. 1-2, pp. 43–58, 1987. View at Google Scholar · View at Scopus
  17. E. Cherubini, M. R. de Feo, O. Mecarelli, and G. F. Ricci, “Behavioral and electrographic patterns induced by systemic administration of kainic acid in developing rats,” Brain Research, vol. 285, no. 1, pp. 69–77, 1983. View at Google Scholar · View at Scopus
  18. G. L. Holmes, “Epilepsy in the developing brain: lessons from the laboratory and clinic,” Epilepsia, vol. 38, no. 1, pp. 12–30, 1997. View at Publisher · View at Google Scholar · View at Scopus
  19. S. L. Moshe, “The effects of age on the kindling phenomenon,” Developmental Psychobiology, vol. 14, no. 1, pp. 75–81, 1981. View at Google Scholar · View at Scopus
  20. Y. Kakisaka, K. Haginoya, M. Ishitobi et al., “Utility of subtraction ictal SPECT images in detecting focal leading activity and understanding the pathophysiology of spasms in patients with west syndrome,” Epilepsy Research, vol. 83, no. 2-3, pp. 177–183, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. H. T. Chugani, D. A. Shewmon, R. Sankar, B. C. Chen, and M. E. Phelps, “Infantile spasms: II. Lenticular nuclei and brain stem activation on positron emission tomography,” Annals of Neurology, vol. 31, no. 2, pp. 212–219, 1992. View at Google Scholar · View at Scopus
  22. J. N. Acharya, E. Wyllie, H. O. Lüders, P. Kotagal, M. Lancman, and M. Coelho, “Seizure symptomatology in infants with localization-related epilepsy,” Neurology, vol. 48, no. 1, pp. 189–196, 1997. View at Google Scholar · View at Scopus
  23. A. Olbrich, L. Urak, G. Gröppel et al., “Semiology of temporal lobe epilepsy in children and adolescents value in lateralizing the seizure onset zone,” Epilepsy Research, vol. 48, no. 1-2, pp. 103–110, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. E. Wyllie, M. Chee, M. L. Granstrom et al., “Temporal lobe epilepsy in early childhood,” Epilepsia, vol. 34, no. 5, pp. 859–868, 1993. View at Google Scholar · View at Scopus
  25. E. Fontana, F. Negrini, S. Francione et al., “Temporal lobe epilepsy in children: electroclinical study of 77 cases,” Epilepsia, vol. 47, supplement s5, pp. 26–30, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. L. Oller-Daurella and L. F. Oller, “Partial epilepsy with seizures appearing in the first three years of life,” Epilepsia, vol. 30, no. 6, pp. 820–826, 1989. View at Google Scholar · View at Scopus
  27. V. Villanueva and J. M. Serratosa, “Temporal lobe epilepsy: clinical semiology and age at onset,” Epileptic Disorders, vol. 7, no. 2, pp. 83–90, 2005. View at Google Scholar · View at Scopus
  28. I. Tuxhorn, H. Holthausen, and H. Boenigk, Eds., Paediatric Epilepsy Syndromes and Their Surgical Treatment, John Libbey and Company Ltd, London, UK, 1997.
  29. M. Feichtinger, E. Pauli, I. Schäfer et al., “Ictal fear in temporal lobe epilepsy: surgical outcome and focal hippocampal changes revealed by proton magnetic resonance spectroscopy imaging,” Archives of Neurology, vol. 58, no. 5, pp. 771–777, 2001. View at Google Scholar · View at Scopus
  30. D. F. Clarke, H. Otsubo, S. K. Weiss et al., “The significance of ear plugging in localization-related epilepsy,” Epilepsia, vol. 44, no. 12, pp. 1562–1567, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Vendrame, M. Zarowski, A. V. Alexopoulos, E. Wyllie, S. V. Kothare, and T. Loddenkemper, “Localization of pediatric seizure semiology,” Clinical Neurophysiology, vol. 122, no. 10, pp. 1924–1928, 2011. View at Google Scholar
  32. P. Kotagal, H. Luders, H. H. Morris et al., “Dystonic posturing in complex partial seizures of temporal lobe onset: a new lateralizing sign,” Neurology, vol. 39, no. 2, pp. 196–201, 1989. View at Google Scholar · View at Scopus
  33. M. A. Peppercorn and A. G. Herzog, “The spectrum of abdominal epilepsy in adults,” American Journal of Gastroenterology, vol. 84, no. 10, pp. 1294–1296, 1989. View at Google Scholar · View at Scopus
  34. B. D. Moseley, E. C. Wirrell, K. Nickels, J. N. Johnson, M. J. Ackerman, and J. Britton, “Electrocardiographic and oximetric changes during partial complex and generalized seizures,” Epilepsy Research, vol. 95, no. 3, pp. 237–245, 2011. View at Publisher · View at Google Scholar
  35. H. Mayer, F. Benninger, L. Urak, B. Plattner, J. Geldner, and M. Feucht, “EKG abnormalities in children and adolescents with symptomatic temporal lobe epilepsy,” Neurology, vol. 63, no. 2, pp. 324–328, 2004. View at Google Scholar · View at Scopus
  36. B. D. Moseley, K. Nickels, J. Britton, and E. Wirrell, “How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures?” Epilepsia, vol. 51, no. 7, pp. 1219–1224, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Watanabe, K. Hara, S. Hakamada et al., “Seizures with apnea in children,” Pediatrics, vol. 70, no. 1, pp. 87–90, 1982. View at Google Scholar · View at Scopus
  38. M. R. Sperling and J. Engel Jr, “Electroencephalographic recording from the temporal lobes: a comparison of ear, anterior temporal, and nasopharyngeal electrodes,” Annals of Neurology, vol. 17, no. 5, pp. 510–513, 1985. View at Google Scholar · View at Scopus
  39. L. F. Quesney, “Extracranial EEG evaluation,” in Surgical Treatment of the Epilepsies, J. Engel Jr, Ed., pp. 129–166, Raven Press, New York, NY, USA, 1987. View at Google Scholar
  40. F. W. Sharbrough, “Commentary: extracranial EEG monitoring,” in Surgical Treatment of the Epilepsies, J. Engel Jr, Ed., pp. 167–171, Raven Press, New York, NY, USA, 1987. View at Google Scholar
  41. F. W. Sharbrough, “Electrical fields and recording techniques,” in Current Practice of Clinical Electroencephalography, D. Daly and T. A. Pedley, Eds., pp. 29–49, Raven Press, New York, NY, USA, 1990. View at Google Scholar
  42. B. F. Westmoreland, “The electroencephalogram in patients with epilepsy,” in Neurology Clinics, M. J. Aminoff, Ed., pp. 599–613, WB Saunders, Philadelphia, Pa, USA, 1985. View at Google Scholar
  43. E. Wyllie, D. K. Lachhwani, A. Gupta et al., “Successful surgery for epilepsy due to early brain lesions despite generalized EEG findings,” Neurology, vol. 69, no. 4, pp. 389–397, 2007. View at Publisher · View at Google Scholar · View at Scopus
  44. J. Gotman and M. G. Marciani, “Electroencephalographic spiking activity, drug levels, and seizure occurrence in epileptic patients,” Annals of Neurology, vol. 17, no. 6, pp. 597–603, 1985. View at Google Scholar · View at Scopus
  45. A. T. Berg, S. F. Berkovic, M. J. Brodie et al., “Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE commission on classification and terminology, 2005–2009,” Epilepsia, vol. 51, no. 4, pp. 676–685, 2010. View at Publisher · View at Google Scholar · View at Scopus
  46. R. Michelucci, E. Pasini, and C. Nobile, “Lateral temporal lobe epilepsies: clinical and genetic features,” Epilepsia, vol. 50, supplement 5, pp. 52–54, 2009. View at Publisher · View at Google Scholar · View at Scopus
  47. R. Ottman, M. R. Winawer, S. Kalachikov et al., “LGI1 mutations in autosomal dominant partial epilepsy with auditory features,” Neurology, vol. 62, no. 7, pp. 1120–1126, 2004. View at Google Scholar · View at Scopus
  48. F. Bisulli, P. Tinuper, P. Avoni et al., “Idiopathic partial epilepsy with auditory features (IPEAF): a clinical and genetic study of 53 sporadic cases,” Brain, vol. 127, no. 6, pp. 1343–1352, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. D. E. Crompton, I. E. Scheffer, I. Taylor et al., “Familial mesial temporal lobe epilepsy: a benign epilepsy syndrome showing complex inheritance,” Brain, vol. 133, no. 11, pp. 3221–3231, 2010. View at Publisher · View at Google Scholar · View at Scopus
  50. L. Maillard, J. P. Vignal, E. Raffo, and H. Vespignani, “Bitemporal form of partial reading epilepsy: further evidence for an idiopathic localization-related syndrome,” Epilepsia, vol. 51, no. 1, pp. 165–169, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. G. Möddel, T. Lineweaver, S. U. Schuele, J. Reinholz, and T. Loddenkemper, “Atypical language lateralization in epilepsy patients,” Epilepsia, vol. 50, no. 6, pp. 1505–1516, 2009. View at Publisher · View at Google Scholar · View at Scopus
  52. M. E. Peltola, E. Liukkonen, M. L. Granstrom et al., “The effect of surgery in encephalopathy with electrical status epilepticus during sleep,” Epilepsia, vol. 52, no. 3, pp. 602–609, 2011. View at Publisher · View at Google Scholar
  53. K. Nickels and E. Wirrell, “Electrical status epilepticus in sleep,” Seminars in Pediatric Neurology, vol. 15, no. 2, pp. 50–60, 2008. View at Publisher · View at Google Scholar · View at Scopus
  54. P. G. Rossi, A. Parmeggiani, A. Posar, M. C. Scaduto, S. Chiodo, and G. Vatti, “Landau-Kleffner syndrome (LKS): long-term follow-up and links with electrical status epilepticus during sleep (ESES),” Brain and Development, vol. 21, no. 2, pp. 90–98, 1999. View at Publisher · View at Google Scholar · View at Scopus
  55. P. B. Jayakar and S. S. Seshia, “Electrical status epilepticus during slow-wave sleep: a review,” Journal of Clinical Neurophysiology, vol. 8, no. 3, pp. 299–311, 1991. View at Google Scholar · View at Scopus
  56. A. S. Galanopoulou, A. Bojko, F. Lado, and S. L. Moshé, “The spectrum of neuropsychiatric abnormalities associated with electrical status epilepticus in sleep,” Brain and Development, vol. 22, no. 5, pp. 279–295, 2000. View at Publisher · View at Google Scholar · View at Scopus
  57. L. Nieuwenhuis and J. Nicolai, “The pathophysiological mechanisms of cognitive and behavioral disturbances in children with Landau-Kleffner syndrome or epilepsy with continuous spike-and-waves during slow-wave sleep,” Seizure, vol. 15, no. 4, pp. 249–258, 2006. View at Publisher · View at Google Scholar · View at Scopus
  58. R. D. Sheth, “Electroencephalogram in developmental delay: specific electroclinical syndromes,” Seminars in Pediatric Neurology, vol. 5, no. 1, pp. 45–51, 1998. View at Publisher · View at Google Scholar · View at Scopus
  59. R. F. Tuchman and I. Rapin, “Regression in pervasive developmental disorders: seizures and epileptiform electroencephalogram correlates,” Pediatrics, vol. 99, no. 4, pp. 560–566, 1997. View at Google Scholar · View at Scopus
  60. K. A. McVicar and S. Shinnar, “Landau-Kleffner syndrome, electrical status epilepticus in slow wave sleep, and language regression in children,” Mental Retardation and Developmental Disabilities Research Reviews, vol. 10, no. 2, pp. 144–149, 2004. View at Publisher · View at Google Scholar · View at Scopus
  61. C. A. Tassinari, G. Rubboli, L. Volpi et al., “Encephalopathy with electrical status epilepticus during slow sleep or ESES syndrome including the acquired aphasia,” Clinical Neurophysiology, vol. 111, supplement 2, pp. S94–S102, 2000. View at Publisher · View at Google Scholar · View at Scopus
  62. C. A. Tassinari, R. Michelucci, A. Forti et al., “The electrical status epilepticus syndrome,” Epilepsy Research Supplement, vol. 6, pp. 111–115, 1992. View at Google Scholar · View at Scopus
  63. E. R. Perez, “Syndromes of acquired epileptic aphasia and epilepsy with continuous spike-waves during sleep: models for prolonged cognitive impairment of epileptic origin,” Seminars in Pediatric Neurology, vol. 2, no. 4, pp. 269–277, 1995. View at Google Scholar · View at Scopus
  64. W. S. MacAllister and S. G. Schaffer, “Neuropsychological deficits in childhood epilepsy syndromes,” Neuropsychology Review, vol. 17, no. 4, pp. 427–444, 2007. View at Publisher · View at Google Scholar · View at Scopus
  65. S. Debiais, L. Tuller, M. A. Barthez et al., “Epilepsy and language development: the continuous spike-waves during slow sleep syndrome,” Epilepsia, vol. 48, no. 6, pp. 1104–1110, 2007. View at Publisher · View at Google Scholar · View at Scopus
  66. R. F. Tuchman, “Epilepsy, language, and behavior: clinical models in childhood,” Journal of Child Neurology, vol. 9, no. 1, pp. 95–102, 1994. View at Google Scholar · View at Scopus
  67. M. de Negri, “Electrical status epilepticus during sleep (ESES). Different clinical syndromes: towards a unifying view?” Brain and Development, vol. 19, no. 7, pp. 447–451, 1997. View at Publisher · View at Google Scholar · View at Scopus
  68. C. A. Tassinnari, M. Bureau, C. Dravet, B. D. Bernardina, and J. Roger, “Epilepsy with continuous spikes and waves during slow sleep—otherwise described as ESES,” in Epileptic Syndromes in Infancy, Childhood and Adolescence, J. Roger, M. Bureau, C. Dravet, F. E. Dreifuss, A. Perret, and P. Wolf, Eds., pp. 245–256, John Libbey, London, UK, 1992. View at Google Scholar
  69. A. Beaumanoir, “EEG data,” in Continuous Spikes and Waves During Slow Sleep, A. Beaumanoir, M. Bureau, T. Deonna, L. Mira, and C. A. Tassinari, Eds., pp. 217–223, John Libbey, London, UK, 1995. View at Google Scholar
  70. M. C. Smith and T. J. Hoeppner, “Epileptic encephalopathy of late childhood: Landau-Kleffner syndrome and the syndrome of continuous spikes and waves during slow-wave sleep,” Journal of Clinical Neurophysiology, vol. 20, no. 6, pp. 462–472, 2003. View at Publisher · View at Google Scholar · View at Scopus
  71. J. Roger, F. E. Dreifuss, M. Martinez-Lage et al., “Proposal for revised classification of epilepsies and epileptic syndromes. Commission on classification and terminology of the international league against epilepsy,” Epilepsia, vol. 30, no. 4, pp. 389–399, 1989. View at Google Scholar
  72. L. J. Willmore and Y. Ueda, “Genetics of epilepsy,” Journal of Child Neurology, vol. 17, supplement 1, pp. S18–S27, 2002. View at Google Scholar · View at Scopus
  73. C. P. Panayiotopoulos, M. Michael, S. Sanders, T. Valeta, and M. Koutroumanidis, “Benign childhood focal epilepsies: assessment of established and newly recognized syndromes,” Brain, vol. 131, no. 9, pp. 2264–2286, 2008. View at Publisher · View at Google Scholar · View at Scopus
  74. J. A. French, A. M. Kanner, J. Bautista et al., “Efficacy and tolerability of the new antiepileptic drugs II: treatment of refractory epilepsy: report of the therapeutics and technology assessment subcommittee and quality standards subcommittee of the American academy of neurology and the American epilepsy society,” Neurology, vol. 62, no. 8, pp. 1261–1273, 2004. View at Google Scholar · View at Scopus
  75. P. Kwan and M. J. Brodie, “Early identification of refractory epilepsy,” New England Journal of Medicine, vol. 342, no. 5, pp. 314–319, 2000. View at Publisher · View at Google Scholar · View at Scopus
  76. R. Mohanraj and M. J. Brodie, “Diagnosing refractory epilepsy: response to sequential treatment schedules,” European journal of neurology, vol. 13, no. 3, pp. 277–282, 2006. View at Publisher · View at Google Scholar
  77. H. A. Carpay, W. F. Arts, A. T. Geerts et al., “Epilepsy in childhood: an audit of clinical practice,” Archives of Neurology, vol. 55, no. 5, pp. 668–673, 1998. View at Publisher · View at Google Scholar · View at Scopus
  78. A. T. Berg, S. R. Levy, F. M. Testa, and R. d'Souza, “Remission of epilepsy after two drug failures in children: a prospective study,” Annals of Neurology, vol. 65, no. 5, pp. 510–519, 2009. View at Publisher · View at Google Scholar · View at Scopus
  79. L. C. Elkis, B. F. D. Bourgeois, E. Wyllie, and P. Kotagal, “Efficacy of second antiepileptic drug after failure of one drug in children with partial epilepsy,” Epilepsia, vol. 34, supplement 6, 107 pages, 1993. View at Google Scholar
  80. F. Semah, M. C. Picot, C. Adam et al., “Is the underlying cause of epilepsy a major prognostic factor for recurrence?” Neurology, vol. 51, no. 5, pp. 1256–1262, 1998. View at Google Scholar · View at Scopus
  81. D. J. Dlugos, “The early identification of candidates for epilepsy surgery,” Archives of Neurology, vol. 58, no. 10, pp. 1543–1546, 2001. View at Google Scholar · View at Scopus
  82. U. Gleissner, R. Sassen, J. Schramm, C. E. Elger, and C. Helmstaedter, “Greater functional recovery after temporal lobe epilepsy surgery in children,” Brain, vol. 128, no. 12, pp. 2822–2829, 2005. View at Publisher · View at Google Scholar · View at Scopus
  83. D. B. Sinclair, K. E. Aronyk, T. J. Snyder et al., “Pediatric epilepsy surgery at the University of Alberta: 1988–2000,” Pediatric Neurology, vol. 29, no. 4, pp. 302–311, 2003. View at Publisher · View at Google Scholar · View at Scopus
  84. M. L. Bell, S. Rao, E. L. So et al., “Epilepsy surgery outcomes in temporal lobe epilepsy with a normal MRI,” Epilepsia, vol. 50, no. 9, pp. 2053–2060, 2009. View at Publisher · View at Google Scholar · View at Scopus
  85. J. X. Tao, M. Baldwin, S. Hawes-Ebersole, and J. S. Ebersole, “Cortical substrates of scalp EEG epileptiform discharges,” Journal of Clinical Neurophysiology, vol. 24, no. 2, pp. 96–100, 2007. View at Publisher · View at Google Scholar
  86. N. J. Azar, A. H. Lagrange, and B. W. Abou-Khalil, “Transitional sharp waves at ictal onset—a neocortical ictal pattern,” Clinical Neurophysiology, vol. 120, no. 4, pp. 665–672, 2009. View at Publisher · View at Google Scholar · View at Scopus
  87. J. S. Ebersole and S. V. Pacia, “Localization of temporal lobe foci by ictal EEG patterns,” Epilepsia, vol. 37, no. 4, pp. 386–399, 1996. View at Publisher · View at Google Scholar · View at Scopus
  88. J. X. Tao, X. J. Chen, M. Baldwin et al., “Interictal regional delta slowing is an EEG marker of epileptic network in temporal lobe epilepsy,” Epilepsia, vol. 52, no. 3, pp. 467–476, 2011. View at Publisher · View at Google Scholar
  89. A. M. McIntosh, R. M. Kalnins, L. A. Mitchell, G. C. Fabinyi, R. S. Briellmann, and S. F. Berkovic, “Temporal lobectomy: long-term seizure outcome, late recurrence and risks for seizure recurrence,” Brain, vol. 127, no. 9, pp. 2018–2030, 2004. View at Publisher · View at Google Scholar · View at Scopus
  90. F. G. Woermann and C. Vollmar, “Clinical MRI in children and adults with focal epilepsy: a critical review,” Epilepsy and Behavior, vol. 15, no. 1, pp. 40–49, 2009. View at Publisher · View at Google Scholar · View at Scopus
  91. A. Labate, A. Gambardella, U. Aguglia et al., “Temporal lobe abnormalities on brain MRI in healthy volunteers: a prospective case-control study,” Neurology, vol. 74, no. 7, pp. 553–557, 2010. View at Publisher · View at Google Scholar · View at Scopus
  92. G. D. Cascino, “Clinical correlations with hippocampal atrophy,” Magnetic Resonance Imaging, vol. 13, no. 8, pp. 1133–1136, 1995. View at Publisher · View at Google Scholar · View at Scopus
  93. T. J. O'Brien, E. L. So, B. P. Mullan et al., “Subtraction SPECT co-registered to MRI improves postictal SPECT localization of seizure loci,” Neurology, vol. 52, no. 1, pp. 137–146, 1999. View at Google Scholar · View at Scopus
  94. E. L. So, “Integration of EEG, MRI, and SPECT in localizing the seizure focus for epilepsy surgery,” Epilepsia, vol. 41, supplement 3, pp. S48–S54, 2000. View at Google Scholar · View at Scopus
  95. O. Willmann, R. Wennberg, T. May, F. G. Woermann, and B. Pohlmann-Eden, “The contribution of 18F-FDG PET in preoperative epilepsy surgery evaluation for patients with temporal lobe epilepsy. A meta-analysis,” Seizure, vol. 16, no. 6, pp. 509–520, 2007. View at Publisher · View at Google Scholar · View at Scopus
  96. K. Kaiboriboon, S. Nagarajan, M. Mantle, and H. E. Kirsch, “Interictal MEG/MSI in intractable mesial temporal lobe epilepsy: spike yield and characterization,” Clinical Neurophysiology, vol. 121, no. 3, pp. 325–331, 2010. View at Publisher · View at Google Scholar · View at Scopus
  97. E. Pataraia, G. Lindinger, L. Deecke, D. Mayer, and C. Baumgartner, “Combined MEG/EEG analysis of the interictal spike complex in mesial temporal lobe epilepsy,” NeuroImage, vol. 24, no. 3, pp. 607–614, 2005. View at Publisher · View at Google Scholar · View at Scopus
  98. J. J. Shih, M. P. Weisend, J. Lewine, J. Sanders, J. Dermon, and R. Lee, “Areas of interictal spiking are associated with metabolic dysfunction in MRI-negative temporal lobe epilepsy,” Epilepsia, vol. 45, no. 3, pp. 223–229, 2004. View at Publisher · View at Google Scholar · View at Scopus
  99. J. J. Shih, M. P. Weisend, J. A. Sanders, and R. R. Lee, “Magnetoencephalographic and magnetic resonance spectroscopy evidence of regional functional abnormality in mesial temporal lobe epilepsy,” Brain Topography, vol. 23, no. 4, pp. 368–374, 2010. View at Publisher · View at Google Scholar · View at Scopus
  100. W. Series, L. M. Li, Z. Caramanos, D. L. Arnold, and J. Gotman, “Relation of interictal spike frequency to 1H-MRSI-measured NAA/Cr,” Epilepsia, vol. 40, no. 12, pp. 1821–1827, 1999. View at Google Scholar · View at Scopus
  101. J. H. Cross, A. Connelly, G. D. Jackson, C. L. Johnson, B. G. Neville, and D. G. Gadian, “Proton magnetic resonance spectroscopy in children with temporal lobe epilepsy,” Annals of Neurology, vol. 39, no. 1, pp. 107–113, 1996. View at Publisher · View at Google Scholar · View at Scopus
  102. D. G. Gadian, E. B. Isaacs, J. H. Cross et al., “Lateralization of brain function in childhood revealed by magnetic resonance spectroscopy,” Neurology, vol. 46, no. 4, pp. 974–977, 1996. View at Google Scholar · View at Scopus
  103. P. R. Camfield, R. Gates, and G. Ronen, “Comparison of cognitive ability, personality profile, and school success in epileptic children with pure right versus left temporal lobe EEG foci,” Annals of Neurology, vol. 15, no. 2, pp. 122–126, 1984. View at Publisher · View at Google Scholar
  104. C. Helmstaedter and C. E. Elger, “Chronic temporal lobe epilepsy: a neurodevelopmental or progressively dementing disease,” Brain, vol. 132, no. 10, pp. 2822–2830, 2009. View at Publisher · View at Google Scholar · View at Scopus
  105. D. S. Kadis, E. N. Kerr, J. T. Rutka, O. C. Snead III, S. K. Weiss, and M. L. Smith, “Pathology type does not predict language lateralization in children with medically intractable epilepsy,” Epilepsia, vol. 50, no. 6, pp. 1498–1504, 2009. View at Publisher · View at Google Scholar · View at Scopus
  106. G. P. Lee, M. Westerveld, L. B. Blackburn, Y. D. Park, and D. W. Loring, “Prediction of verbal memory decline after epilepsy surgery in children: effectiveness of Wada memory asymmetries,” Epilepsia, vol. 46, no. 1, pp. 97–103, 2005. View at Publisher · View at Google Scholar · View at Scopus
  107. C. A. Szabo and E. Wyllie, “Intracarotid amobarbital testing for language and memory dominance in children,” Epilepsy Research, vol. 15, no. 3, pp. 239–246, 1993. View at Publisher · View at Google Scholar · View at Scopus
  108. J. R. Binder, D. S. Sabsevitz, S. J. Swanson, T. A. Hammeke, M. Raghavan, and W. M. Mueller, “Use of preoperative functional MRI to predict verbal memory decline after temporal lobe epilepsy surgery,” Epilepsia, vol. 49, no. 8, pp. 1377–1394, 2008. View at Publisher · View at Google Scholar · View at Scopus
  109. L. Frings, K. Wagner, U. Halsband, R. Schwarzwald, J. Zentner, and A. Schulze-Bonhage, “Lateralization of hippocampal activation differs between left and right temporal lobe epilepsy patients and correlates with postsurgical verbal learning decrement,” Epilepsy Research, vol. 78, no. 2-3, pp. 161–170, 2008. View at Publisher · View at Google Scholar · View at Scopus
  110. A. Datta, D. B. Sinclair, M. Wheatley et al., “Selective amygdalohippocampectomy: surgical outcome in children versus adults,” Canadian Journal of Neurological Sciences, vol. 36, no. 2, pp. 187–191, 2009. View at Google Scholar · View at Scopus
  111. H. Clusmann, T. Kral, U. Gleissner et al., “Analysis of different types of resection for pediatric patients with temporal lobe epilepsy,” Neurosurgery, vol. 54, no. 4, pp. 847–860, 2004. View at Google Scholar · View at Scopus
  112. T. H. Schwartz, C. W. Bazil, T. S. Walczak, S. Chan, T. A. Pedley, and R. R. Goodman, “The predictive value of intraoperative electrocorticography in resections for limbic epilepsy associated with mesial temporal sclerosis,” Neurosurgery, vol. 40, no. 2, pp. 302–311, 1997. View at Publisher · View at Google Scholar · View at Scopus
  113. G. M. Mckhann II, J. Schoenfeld-McNeill, D. E. Born, M. M. Haglund, and G. A. Ojemann, “Intraoperative hippocampal electrocorticography to predict the extent of hippocampal resection in temporal lobe epilepsy surgery,” Journal of Neurosurgery, vol. 93, no. 1, pp. 44–52, 2000. View at Google Scholar · View at Scopus
  114. A. Kuruvilla and R. Flink, “Intraoperative electrocorticography in epilepsy surgery: useful or not?” Seizure, vol. 12, no. 8, pp. 577–584, 2003. View at Publisher · View at Google Scholar
  115. M. Lassonde, H. C. Sauerwein, I. Jambaque, M. L. Smith, and C. Helmstaedter, “Neuropsychology of childhood epilepsy: pre- and postsurgical assessment,” Epileptic Disorders, vol. 2, no. 1, pp. 3–13, 2000. View at Google Scholar
  116. D. Yam, D. Nicolle, D. A. Steven, D. Lee, T. Hess, and J. G. Burneo, “Visual field deficits following anterior temporal lobectomy: long-term follow-up and prognostic implications,” Epilepsia, vol. 51, no. 6, pp. 1018–1023, 2010. View at Publisher · View at Google Scholar · View at Scopus
  117. E. Ramos, S. Benbadis, and F. L. Vale, “Failure of temporal lobe resection for epilepsy in patients with mesial temporal sclerosis: results and treatment options,” Journal of Neurosurgery, vol. 110, no. 6, pp. 1127–1134, 2009. View at Publisher · View at Google Scholar · View at Scopus
  118. E. F. Chang, M. Quigg, M. C. Oh et al., “Predictors of efficacy after stereotactic radiosurgery for medial temporal lobe epilepsy,” Neurology, vol. 74, no. 2, pp. 165–172, 2010. View at Publisher · View at Google Scholar · View at Scopus
  119. F. Bartolomei, M. Hayashi, M. Tamura et al., “Long-term efficacy of γ knife radiosurgery in mesial temporal lobe epilepsy,” Neurology, vol. 70, no. 19, pp. 1658–1663, 2008. View at Publisher · View at Google Scholar · View at Scopus
  120. A. L. Velasco, F. Velasco, M. Velasco, F. Jimenez, J. D. Carrillo-Ruiz, and G. Castro, “The role of neuromodulation of the hippocampus in the treatment of intractable complex partial seizures of the temporal lobe,” Acta Neurochirurgica, Supplementum, no. 97, 2, pp. 329–332, 2007. View at Publisher · View at Google Scholar
  121. A. L. Velasco, F. Velasco, M. Velasco, D. Trejo, G. Castro, and J. D. Carrillo-Ruiz, “Electrical stimulation of the hippocampal epileptic foci for seizure control: a double-blind, long-term follow-up study,” Epilepsia, vol. 48, no. 10, pp. 1895–1903, 2007. View at Publisher · View at Google Scholar · View at Scopus
  122. R. Fisher, V. Salanova, T. Witt et al., “Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy,” Epilepsia, vol. 51, no. 5, pp. 899–908, 2010. View at Publisher · View at Google Scholar · View at Scopus
  123. P. R. Gigante and R. R. Goodman, “Alternative surgical approaches in epilepsy,” Current Neurology and Neuroscience Reports, vol. 11, no. 4, pp. 404–408, 2011. View at Google Scholar
  124. Y. J. Lee, H. C. Kang, S. J. Bae et al., “Comparison of temporal lobectomies of children and adults with intractable temporal lobe epilepsy,” Child's Nervous System, vol. 26, no. 2, pp. 177–183, 2010. View at Publisher · View at Google Scholar · View at Scopus
  125. A. Mohamed, E. Wyllie, P. Ruggieri et al., “Temporal lobe epilepsy due to hippocampal sclerosis in pediatric candidates for epilepsy surgery,” Neurology, vol. 56, no. 12, pp. 1643–1649, 2001. View at Google Scholar · View at Scopus
  126. D. B. Sinclair, M. Wheatley, K. Aronyk et al., “Pathology and neuroimaging in pediatric temporal lobectomy for intractable epilepsy,” Pediatric Neurosurgery, vol. 35, no. 5, pp. 239–246, 2001. View at Publisher · View at Google Scholar · View at Scopus
  127. O. Vernet, J. P. Farmer, J. L. Montes, J. G. Villemure, and K. Meagher-Villemure, “Dysgenetic mesial temporal sclerosis: an unrecognized entity,” Child's Nervous System, vol. 16, no. 10-11, pp. 719–723, 2000. View at Google Scholar · View at Scopus
  128. P. Barsi, J. Kenéz, D. Solymosi et al., “Hippocampal malrotation with normal corpus callosum: a new entity?” Neuroradiology, vol. 42, no. 5, pp. 339–345, 2000. View at Google Scholar · View at Scopus
  129. D. V. Lewis, S. Chan, and J. A. Bello, “HIMAL is a malformation that predisposes to prolonged febrile seizures: data from the FEBSTAT study,” Epilepsia, vol. 47, supplement 4, 16 pages, 2006. View at Google Scholar
  130. R. P. Gamss, S. E. Slasky, J. A. Bello, T. S. Miller, and S. Shinnar, “Prevalence of hippocampal malrotation in a population without seizures,” American Journal of Neuroradiology, vol. 30, no. 8, pp. 1571–1573, 2009. View at Publisher · View at Google Scholar · View at Scopus
  131. E. C. Wirrell, B. R. Grossardt, E. L. So, and K. C. Nickels, “A population-based study of long-term outcomes of cryptogenic focal epilepsy in childhood: cryptogenic epilepsy is probably not symptomatic epilepsy,” Epilepsia, vol. 52, no. 4, pp. 738–745, 2011. View at Publisher · View at Google Scholar
  132. S. Spencer and L. Huh, “Outcomes of epilepsy surgery in adults and children,” The Lancet Neurology, vol. 7, no. 6, pp. 525–537, 2008. View at Publisher · View at Google Scholar · View at Scopus
  133. R. G. Jarrar, J. R. Buchhalter, F. B. Meyer, F. W. Sharbrough, and E. Laws, “Long-term follow-up of temporal lobectomy in children,” Neurology, vol. 59, no. 10, pp. 1635–1637, 2002. View at Google Scholar · View at Scopus
  134. M. Benifla, J. T. Rutka, H. Otsubo et al., “Long-term seizure and social outcomes following temporal lobe surgery for intractable epilepsy during childhood,” Epilepsy Research, vol. 82, no. 2-3, pp. 133–138, 2008. View at Publisher · View at Google Scholar · View at Scopus
  135. B. P. Hermann, M. Seidenberg, B. Bell et al., “The neurodevelopmental impact of childhood onset temporal lobe epilepsy on brain structure and function,” Epilepsia, vol. 43, pp. 1062–1071, 2002. View at Google Scholar
  136. E. M. Sherman, S. Wiebe, T. B. Fay-Mcclymont et al., “Neuropsychological outcomes after epilepsy surgery: systematic review and pooled estimates,” Epilepsia, vol. 52, no. 5, pp. 857–869, 2011. View at Publisher · View at Google Scholar
  137. U. Gleissner, R. Sassen, M. Lendt, H. Clusmann, C. E. Elger, and C. Helmstaedter, “Pre- and postoperative verbal memory in pediatric patients with temporal lobe epilepsy,” Epilepsy Research, vol. 51, no. 3, pp. 287–296, 2002. View at Publisher · View at Google Scholar · View at Scopus
  138. M. Westerveld, K. J. Sass, G. J. Chelune et al., “Temporal lobectomy in children: cognitive outcome,” Journal of Neurosurgery, vol. 92, no. 1, pp. 24–30, 2000. View at Google Scholar · View at Scopus
  139. C. Miranda and M. L. Smith, “Predictors of intelligence after temporal lobectomy in children with epilepsy,” Epilepsy and Behavior, vol. 2, no. 1, pp. 13–19, 2001. View at Publisher · View at Google Scholar · View at Scopus
  140. C. Akos Szabó, E. Wyllie, L. D. Stanford et al., “Neuropsychological effect of temporal lobe resection in preadolescent children with epilepsy,” Epilepsia, vol. 39, no. 8, pp. 814–819, 1998. View at Google Scholar · View at Scopus
  141. C. Skirrow, J. H. Cross, F. Cormack, W. Harkness, F. Vargha-Khadem, and T. Baldeweg, “Long-term intellectual outcome after temporal lobe surgery in childhood,” Neurology, vol. 76, no. 15, pp. 1330–1337, 2011. View at Publisher · View at Google Scholar
  142. M. Rutter, P. Graham, and W. Yule, A Neuropsychiatric Study in Childhood, MacKeith Press, London, UK, 1970.
  143. P. Hoare, “The development of psychiatric disorder among schoolchildren with epilepsy,” Developmental Medicine and Child Neurology, vol. 26, no. 1, pp. 3–13, 1984. View at Google Scholar · View at Scopus
  144. S. Davies, I. Heyman, and R. Goodman, “A population survey of mental health problems in children with epilepsy,” Developmental Medicine and Child Neurology, vol. 45, no. 5, pp. 292–295, 2003. View at Publisher · View at Google Scholar · View at Scopus
  145. D. Ott, R. Caplan, D. Guthrie et al., “Measures of psychopathology in children with complex partial seizures and primary generalized epilepsy with absence,” Journal of the American Academy of Child and Adolescent Psychiatry, vol. 40, no. 8, pp. 907–914, 2001. View at Google Scholar · View at Scopus
  146. A. McLellan, S. Davies, I. Heyman et al., “Psychopathology in children with epilepsy before and after temporal lobe resection,” Developmental Medicine and Child Neurology, vol. 47, no. 10, pp. 666–672, 2005. View at Publisher · View at Google Scholar · View at Scopus
  147. F. Cendes, P. C. Ragazzo, V. da Costa, and L. F. Martins, “Corpus callostomy in treatment of medically resistant epilepsy: preliminary results in a pediatric population,” Epilepsia, vol. 34, no. 5, pp. 910–917, 1993. View at Google Scholar · View at Scopus
  148. M. Lendt, C. Helmstaedter, S. Kuczaty, J. Schramm, and C. E. Elger, “Behavioural disorders in children with epilepsy: early improvement after surgery,” Journal of Neurology Neurosurgery and Psychiatry, vol. 69, no. 6, pp. 739–744, 2000. View at Publisher · View at Google Scholar
  149. E. M. Mizrahi, P. Kellaway, R. G. Grossman et al., “Anterior temporal lobectomy and medically refractory temporal lobe epilepsy of chilchood,” Epilepsia, vol. 31, no. 3, pp. 302–312, 1990. View at Google Scholar · View at Scopus