Table of Contents
Epilepsy Research and Treatment
Volume 2012, Article ID 863702, 19 pages
Review Article

Genetics of Temporal Lobe Epilepsy: A Review

1Department of Psychiatry, University of Geneva 1211 Geneva, Switzerland
2Division of Medical Genetics, Department of Genetic Medicine and Development, University Hospitals of Geneva, 2 Chemin du Petit Bel-Air, 1225 ChĂȘne-Bourg, Switzerland

Received 27 June 2011; Revised 6 November 2011; Accepted 7 December 2011

Academic Editor: Seyed M. Mirsattari

Copyright © 2012 Annick Salzmann and Alain Malafosse. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Temporal lobe epilepsy (TLE) is usually regarded as a polygenic and complex disorder. To understand its genetic component, numerous linkage analyses of familial forms and association studies of cases versus controls have been conducted since the middle of the nineties. The present paper lists genetic findings for TLE from the initial segregation analysis to the most recent results published in May 2011. To date, no genes have been clearly related to TLE despite many efforts to do so. However, it is vital to continue replication studies and collaborative attempts to find significant results and thus determine which gene variant combination plays a definitive role in the aetiology of TLE.