Table of Contents
Epilepsy Research and Treatment
Volume 2013, Article ID 593149, 8 pages
http://dx.doi.org/10.1155/2013/593149
Research Article

A Clinical-EEG Study of Sleepiness and Psychological Symptoms in Pharmacoresistant Epilepsy Patients Treated with Lacosamide

1Neurology Unit and Epilepsy Center, Department of Neuroscience, A.O.U.P and Department of Clinical and Experimental Medicine of the University of Pisa, Via Roma 67, 56126 Pisa, Italy
2Sleep & Epilepsy Center, Neurocenter of the Civic Hospital (EOC) of Lugano, Via Tesserete 46, 6900 Lugano, Switzerland

Received 29 April 2013; Revised 1 August 2013; Accepted 5 August 2013

Academic Editor: Andrea Romigi

Copyright © 2013 Filippo S. Giorgi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Kwan, A. Arzimanoglou, A. T. Berg et al., “Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies,” Epilepsia, vol. 51, no. 6, pp. 1069–1077, 2010. View at Google Scholar
  2. P. Kwan, S. C. Schachter, and M. J. Brodie, “Current concepts: drug-resistant epilepsy,” The New England Journal of Medicine, vol. 365, no. 10, pp. 919–926, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. A. B. Ettinger, “Psychotropic effects of antiepileptic drugs,” Neurology, vol. 67, no. 11, pp. 1916–1925, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. B. Schmitz, “Effects of antiepileptic drugs on mood and behavior,” Epilepsia, vol. 47, no. 2, pp. 28–33, 2006. View at Publisher · View at Google Scholar · View at Scopus
  5. G. Zaccara, P. F. Gangemi, and M. Cincotta, “Central nervous system adverse effects of new antiepileptic drugs. A meta-analysis of placebo-controlled studies,” Seizure, vol. 17, no. 5, pp. 405–421, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. B. Saletu, P. Anderer, G. M. Saletu-Zyhlarz, O. Arnold, and R. D. Pascual-Marqui, “Classification and evaluation of the pharmacodynamics of psychotropic drugs by single-lead pharmaco-EEG, EEG mapping and tomography (LORETA),” Methods and Findings in Experimental and Clinical Pharmacology, vol. 24, pp. 97–120, 2002. View at Google Scholar · View at Scopus
  7. J. D. Frost Jr., R. A. Hrachovy, D. G. Glaze, and G. M. Rettig, “Alpha rhythm slowing during initiation of carbamazepine therapy: implications for future cognitive performance,” Journal of Clinical Neurophysiology, vol. 12, no. 1, pp. 57–63, 1995. View at Google Scholar · View at Scopus
  8. M. C. Salinsky, L. M. Binder, B. S. Oken, D. Storzbach, C. R. Aron, and C. B. Dodrill, “Effects of gabapentin and carbamazepine on the EEG and cognition in healthy volunteers,” Epilepsia, vol. 43, no. 5, pp. 482–490, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. M. C. Salinsky, B. S. Oken, D. Storzbach, and C. B. Dodrill, “Assessment of CNS effects of antiepileptic drugs by using quantitative EEG measures,” Epilepsia, vol. 44, no. 8, pp. 1042–1050, 2003. View at Publisher · View at Google Scholar · View at Scopus
  10. P. Karzmark, P. Zeifert, and J. Barry, “Measurement of depression in epilepsy,” Epilepsy and Behavior, vol. 2, no. 2, pp. 124–128, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. D. Kalogjera-Sackellares and J. C. Sackellares, “Improvement in depression associated with partial epilepsy in patients treated with lamotrigine,” Epilepsy and Behavior, vol. 3, no. 6, pp. 510–516, 2002. View at Publisher · View at Google Scholar · View at Scopus
  12. V. K. Kimiskidis, N. I. Triantafyllou, E. Kararizou et al., “Depression and anxiety in epilepsy: the association with demographic and seizure-related variables,” Annals of General Psychiatry, vol. 6, article 28, 2007. View at Publisher · View at Google Scholar · View at Scopus
  13. A. T. Beck, R. A. Steer, and G. K. Brown, Manual for the Beck Depression Inventory, Psychological Corporation, San Antonio, Tex, USA, 1996.
  14. C. D. Spielberger, R. L. Gorsuch, P. R. Lushene, P. R. Vagg, and G. A. Jacobs, Manual for the State-Trait Anxiety Inventory, Consulting Psychologists Press, Palo Alto, Calif, USA, 1983.
  15. M. W. Johns, “A new method for measuring daytime sleepiness: the Epworth sleepiness scale,” Sleep, vol. 14, no. 6, pp. 540–545, 1991. View at Google Scholar · View at Scopus
  16. L. Vignatelli, G. Plazzi, A. Barbato et al., “GINSEN (Gruppo Italiano Narcolessia Studio Epidemiologico Nazionale), “Italian version of the Epworth sleepiness scale: external validity,” Neurological Sciences, vol. 23, no. 6, pp. 295–300, 2003. View at Google Scholar
  17. A. S. Giorelli, G. S. D. M. L. Neves, M. Venturi, I. M. Pontes, A. Valois, and M. D. M. Gomes, “Excessive daytime sleepiness in patients with epilepsy: a subjective evaluation,” Epilepsy and Behavior, vol. 21, no. 4, pp. 449–452, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. M. W. Johns, “Sleepiness in different situations measured by the Epworth Sleepiness Scale,” Sleep, vol. 17, no. 8, pp. 703–710, 1994. View at Google Scholar · View at Scopus
  19. D. J. Buysse, C. F. Reynolds III, T. H. Monk, S. R. Berman, and D. J. Kupfer, “The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research,” Psychiatry Research, vol. 28, no. 2, pp. 193–213, 1989. View at Google Scholar · View at Scopus
  20. A. Romigi, F. Izzi, F. Placidi et al., “Effects of zonisamide as add-on therapy on sleep-wake cycle in focal epilepsy: a polysomnographic study,” Epilepsy & Behaviour, vol. 26, no. 2, pp. 170–174, 2013. View at Google Scholar
  21. L. B. Krupp, N. G. LaRocca, J. Muir-Nash, and A. D. Steinberg, “The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus,” Archives of Neurology, vol. 46, no. 10, pp. 1121–1123, 1989. View at Google Scholar · View at Scopus
  22. P. O. Valko, C. L. Bassetti, K. E. Bloch, U. Held, and C. R. Baumann, “Validation of the fatigue severity scale in a Swiss cohort,” Sleep, vol. 31, no. 11, pp. 1601–1607, 2008. View at Google Scholar · View at Scopus
  23. M. R. Littner, C. Kushida, M. Wise et al., “Practice parameters for clinical use of the multiple sleep latency test and the maintenance of wakefulness test,” Sleep, vol. 28, no. 1, pp. 113–121, 2005. View at Google Scholar · View at Scopus
  24. M. G. Marciani, G. L. Gigli, F. Stefanini et al., “Effect of carbamazepine on EEG background activity and on interictal epileptiform abnormalities in focal epilepsy,” International Journal of Neuroscience, vol. 70, no. 1-2, pp. 107–116, 1993. View at Google Scholar · View at Scopus
  25. D. Mattia, F. Spanedda, M. A. Bassetti, A. Romigi, F. Placidi, and M. G. Marciani, “Gabapentin as add-on therapy in focal epilepsy: a computerized EEG study,” Clinical Neurophysiology, vol. 111, no. 2, pp. 311–317, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. G. L. Gigli and J. Gotman, “Effects of seizures and carbamazepine on interictal spiking in amygdala kindled cats,” Epilepsy Research, vol. 8, no. 3, pp. 204–212, 1991. View at Publisher · View at Google Scholar · View at Scopus
  27. F. Placidi, M. Tombini, A. Romigi et al., “Topiramate: effect on EEG interictal abnormalities and background activity in patients affected by focal epilepsy,” Epilepsy Research, vol. 58, no. 1, pp. 43–52, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. M. G. Marciani, F. Spanedda, M. A. Bassetti et al., “Effect of lamotrigine on EEG paroxysmal abnormalities and background activity: a computerized analysis,” British Journal of Clinical Pharmacology, vol. 42, no. 5, pp. 621–627, 1996. View at Google Scholar · View at Scopus
  29. W. Klimesch, “EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis,” Brain Research Reviews, vol. 29, no. 2-3, pp. 169–195, 1999. View at Publisher · View at Google Scholar · View at Scopus
  30. E. Basar and M. Schurmann, “Brain functioning: integrative models,” in Brain Function and OsillationsIntegrative Brain Function. Neurophysiology and Cognitive Processes, E. Basar, Ed., vol. 2, pp. 393–406, Springer, Berlin, Germany, 1999. View at Google Scholar
  31. M. E. Drake, H. Padamadan, and S. A. Newell, “Interictal quantitative EEG in epilepsy,” Seizure, vol. 7, no. 1, pp. 39–42, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. W. G. Sannita, L. Gervasio, and P. Zagnoni, “Quantitative EEG effects and plasma concentration of sodium valproate: acute and long-term administration to epileptic patients,” Neuropsychobiology, vol. 22, no. 4, pp. 231–235, 1989. View at Google Scholar · View at Scopus
  33. B. Clemens, A. Ménes, P. Piros et al., “Quantitative EEG effects of carbamazepine, oxcarbazepine, valproate, lamotrigine, and possible clinical relevance of the findings,” Epilepsy Research, vol. 70, no. 2-3, pp. 190–199, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Y. Neufeld, E. Kogan, V. Chistik, and A. D. Korczyn, “Comparison of the effects of vigabatrin, lamotrigine, and topiramate on quantitative EEGs in patients with epilepsy,” Clinical Neuropharmacology, vol. 22, no. 2, pp. 80–86, 1999. View at Google Scholar · View at Scopus
  35. G. K. Herkes, T. D. Lagerlund, F. W. Sharbrough, and M. J. Eadie, “Effects of antiepileptic drug treatment on the background frequency of EEGs in epileptic patients,” Journal of Clinical Neurophysiology, vol. 10, no. 2, pp. 210–216, 1993. View at Google Scholar · View at Scopus
  36. K. J. Meador, D. W. Loring, O. L. Abney et al., “Effects of carbamazepine and phenytoin on EEG and memory in healthy adults,” Epilepsia, vol. 34, no. 1, pp. 153–157, 1993. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Mula and F. Monaco, “Antiepileptic drugs and psychopathology of epilepsy: an update,” Epileptic Disorders, vol. 11, no. 1, pp. 1–9, 2009. View at Publisher · View at Google Scholar · View at Scopus
  38. F. G. Gilliam and J. M. Santos, “Adverse psychiatric effects of antiepileptic drugs,” Epilepsy Research, vol. 68, no. 1, pp. 67–69, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. A. R. Giovagnoli and G. Avanzini, “Quality of life and memory performance in patients with temporal lobe epilepsy,” Acta Neurologica Scandinavica, vol. 101, no. 5, pp. 295–300, 2000. View at Publisher · View at Google Scholar · View at Scopus
  40. A. R. Giovagnoli, A. M. Da Silva, A. Federico, and F. Cornelio, “On the personal facets of quality of life in chronic neurological disorders,” Behavioural Neurology, vol. 21, no. 3-4, pp. 155–163, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Kowacs, M. P. Socal, S. C. Ziomkowski et al., “Symptoms of depression and anxiety, and screening for mental disorders in migrainous patients,” Cephalalgia, vol. 23, no. 2, pp. 79–89, 2003. View at Publisher · View at Google Scholar · View at Scopus
  42. G. Zaccara, P. F. Gangemi, and M. Cincotta, “Central nervous system adverse effects of new antiepileptic drugs. A meta-analysis of placebo-controlled studies,” Seizure, vol. 17, no. 5, pp. 405–421, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. A. Shahid, J. Shen, and C. M. Shapiro, “Measurements of sleepiness and fatigue,” Journal of Psychosomatic Research, vol. 69, no. 1, pp. 81–89, 2010. View at Publisher · View at Google Scholar · View at Scopus