Table of Contents
Epilepsy Research and Treatment
Volume 2013, Article ID 670682, 8 pages
Review Article

Epilepsy, Antiseizure Therapy, and Sleep Cycle Parameters

Department of Neurology, Barrow Neurological Institute, 500 West Thomas Road, Suite 720, Phoenix, AZ 85013, USA

Received 15 March 2013; Revised 4 July 2013; Accepted 18 July 2013

Academic Editor: Andrea Romigi

Copyright © 2013 Vladimir Shvarts and Steve Chung. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A reciprocal relationship exists between sleep and epilepsy. The quality of sleep is affected by the presence and frequency of seizures, type of antiepileptic therapy utilized, and coexisting primary sleep disorders. Daytime somnolence is one of the most common adverse effects of antiepileptic therapy, with specific pharmacologic agents exhibiting a unique influence on components of sleep architecture. The newer generation of antiseizure drugs demonstrates improved sleep efficiency, greater stabilization of sleep architecture, prolongation of REM sleep duration, and increased quality of life measures. The emerging field of chronoepileptology explores the relationship between seizures and circadian rhythms, aiming for targeted use of antiseizure therapies to maximize therapeutic effects and minimize the adverse events experienced by the patients.