Table of Contents
Epilepsy Research and Treatment
Volume 2014, Article ID 157452, 9 pages
http://dx.doi.org/10.1155/2014/157452
Research Article

Episodic and Semantic Autobiographical Memory in Temporal Lobe Epilepsy

1Epilepsy Center, Neurology Division, Ramos Mejia Hospital, Gral Urquiza 609, C1221ADC Buenos Aires, Argentina
2Center for Clinical and Experimental Neurosciences, Epilepsy, Cognition and Behavior, Institute of Cell Biology and Neurosciences (IBCN), School of Medicine, UBA-CONICET, 2nd Floor, Paraguay 2155, C1121ABG Buenos Aires, Argentina
3National Neuroscience Center, Epilepsy Unit, El Cruce Hospital, Avenue Calchaquí 5401, C1888, Florencio Varela, C1073ABA Buenos Aires, Argentina

Received 28 July 2014; Revised 18 November 2014; Accepted 18 November 2014; Published 8 December 2014

Academic Editor: Louis Lemieux

Copyright © 2014 Claudia P. Múnera et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Autobiographical memory (AM) is understood as the retrieval of personal experiences that occurred in specific time and space. To date, there is no consensus on the role of medial temporal lobe structures in AM. Therefore, we investigated AM in medial temporal lobe epilepsy (TLE) patients. Twenty TLE patients candidates for surgical treatment, 10 right (RTLE) and 10 left (LTLE), and 20 healthy controls were examined with a version of the Autobiographical Interview adapted to Spanish language. Episodic and semantic AM were analyzed during five life periods through two conditions: recall and specific probe. AM scores were compared with clinical and cognitive data. TLE patients showed lower performance in episodic AM than healthy controls, being significantly worst in RTLE group and after specific probe. In relation to semantic AM, LTLE retrieved higher amount of total semantic details compared to controls during recall, but not after specific probe. No significant differences were found between RTLE and LTLE, but a trend towards poorer performance in RTLE group was found. TLE patients obtained lower scores for adolescence period memories after specific probe. Our findings support the idea that the right hippocampus would play a more important role in episodic retrieval than the left, regardless of a temporal gradient.