The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy
Figure 1
Observed versus expected pentapeptide matching between TT and epilepsy-related proteins. The 42 proteins sharing pentapeptides with TT are allocated along the -axis according to increasing aa length. Gray columns: expected matches calculated according to the formula , where is the number of pentapeptides present in the neurotoxin (1,311) and is the number of pentapeptides present in the epilepsy-associated protein (see Methods). For example, in the case of IR3IP protein, 82aa, the possible pentapeptide overlap is equal to 1,311 × 78/3,200,000 + 1,311/2. Black columns: observed to expected ratio of the pentapeptide matching. Observed matching values from Box 2.
