The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy

Box 1

List of the 133 epilepsy-associated proteins analyzed for TT pentapeptide sharing. Proteins were randomly retrieved from UniProtKB (http://www.uniprot.org/) as described under Methods. Proteins are indicated by UniProtKB/Swiss-Prot entry names, and listed according to increasing aa length reported in parentheses.

IR3IP (82); CYTB (98); MPC1 (109); OPALI (141); ARF6 (175); DYR (187); CP013 (204); GOSR2 (212);

RB39B (213); SCN1B (218); THEM4 (240); FOLR1 (257); PNPO (261); CLN8 (286); ROGDI (287); KCTD7

(289); SEN34 (310); CLN6 (311); PPR3C (317); PRS41 (318); GHC1 (323); EPM2A (331); PRRT2 (340);

EP2A2 (344); RENR (350); MPRB (354); CLN5 (358); PHF6 (365); LIAS (372); IRK10 (379); CYB (380);

AMACR (382); IRK11 (390); NHLC1 (395); ASAH1 (395); SNIP1 (396); ARC (396); NAGAB (411); BCKD

(412); SIAT9 (418); STRAA (431); CBPA6 (437); DCX (441); PH4H (452); IDHP (452); GBRD (452); GBRA1

(456); NDUV1 (464); MK10 (464); SRPX2 (465); SEN2 (465); GBRG2 (467); MEF2C (473); GBRB3 (473);

SCRB2 (478); AKT1 (480); PUR8 (484); GTR1 (492); KCNA1 (495); KCNV1 (500); ACHB2 (502); ARHG9

(516); JERKY (520); CACB4 (520); D2HDH (521); LRRC1 (524); SEN54 (526); ACHA2 (529); LGI4 (537);

AL7A1 (539); LGI2 (545); LGI3 (548); LGI1 (557); TBC24 (559); ARX (562); TPP1 (563); GGT3 (568); PUR9

(592); STXB1 (594); DCE1 (594); EPMIP (607); LBR (615); ACHA4 (627); EFHC1 (640); SL9A9 (645); ITF2

(667); TSEAR (669); SL9A6 (669); SYN1 (705); EFHC2 (749); TRM44 (757); AFG32 (797); BRAT1 (821);

PRIC1 (831); PRIC2 (844); KCNQ3 (872); KCNQ2 (872); SOBP (873); MANBA (879); CLCN2 (898); PWP2

(919); GABR1 (961); MIB1 (1006); CDKL5 (1030); AT2A2 (1042); DLGP2 (1054); CASR (1078); AP4E1

(1137); PCD19 (1148); TSC1 (1164); ATN1 (1190); ZEB2 (1214); PLCB1 (1216); KCMA1 (1236); DPOG1

(1239); TPC10 (1259); CNTP2 (1331); ARHGA (1369); NMDE1 (1464); WDR62 (1518); ABCC8 (1581);

GCP6 (1819); SCN8A (1980); SCN9A (1988); SCN2A (2005); SCN1A (2009); CAC1E (2313); CAC1H (2353);

SPTN1 (2472); VP13A (3174); RELN (3460); CSMD3 (3707); GPR98 (6306)