The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy

Box 2

Peptide sharing between TT and epilepsy-associated proteins. Proteins reported by UniProtKB/Swiss-Prot entry names and listed according to the aa length. Pentapeptides shared with TT are italic in parentheses. Pentapeptides present more than once in the epilepsy antigen set are underlined. Sharing of two consecutively overlapped pentapeptides (i.e., a hexapeptide) is indicated by an asterisk.

ROGDI (LKDKI); CLN6 (PALLL); CLN5 (VIVHK); NHLC1 (TITND); ASAH1 (PVLNK); CBPA6 (GIPYA);

GBRA1 (VSFWL); MK10 (SVDDAL*, GAQGI); GTR1 (SYLSI); ARHG9 (KLEEK); D2HDH (GSGLV);

LRRC1 (NKNEV, SLTDL, FCKAL); ACHA2 (NITSL, EIIPS); LGI2 (KAKWL); LGI1 (GFTEI); EPMIP (SGLVS);

ACHA4 (EIIPS); EFHC1 (RVPKV); SL9A9 (IMYGF); TSEAR (QGYEG); SL9A6 (SIMYG, SPTTL); EFHC2

(GDFIK); AFG32 (DPALL); CLCN2 (TFRDL); PWP2 (GQYIV, HSLSI); GABR1 (EDIDV); CDKL5

(KNSFSE*, SLSIG); TSC1 (LKKLE); KCMA1 (FCKAL, PKEIEK*); CNTP2 (DFIKL); ARHGA (KLVKA);

NMDE1 (PALNI); WDR62 (LIHVL, KRSYQ, TNGKL); GCP6 (SLSIG, KEIEK); SCN8A (FGGQD, DTQSK,

LRVPK, TFLRD); SCN9A (NDMFN); SCN2A (FGGQD, TFLRD); SCN1A (FGGQD, TFLRD); VP13A

(ITMTN); RELN (SIGSG); CSMD3 (EGFNI, KEIEK); GPR98 (LISID, ESKDL, VDGSG, TLPND, SGFNS, LSSAN, VQLKN)