Epilepsy Research and Treatment

Research Article

The Peptide Network between Tetanus Toxin and Human Proteins Associated with Epilepsy

Table 1

Pentapeptide sharing between TT-derived epitopes and human epilepsy-associated proteins.
IEDB ID1TT-derived epitope2,3Immune context Epilepsy-associated proteins4
1270 afcpeyvptfdnvieNITSL HLA-Class II, allele undeterminedACHA2
1389 afrnVDGSGLVSklig HLA-Class II, allele undeterminedGPR98 D2HDH EPMIP
1501 agevrqiTFRDLpdkfnaylHLA-Class II, allele undeterminedCLCN2
1929 aihlvnnesseVIVHKamdiHLA-DRB1*04:01CLN5
2219 akkqllefDTQSKnilmqyi HLA-Class II, allele undeterminedSCN8A
3156 amltnliifgpgPVLNKNEVHLA-Class II, allele undeterminedASAH1 LRRC1
3418 anskfigiteLKKLEskinkHLA-DRB1*11:01TSC1
3832 apsyTNGKLniyyrrlyngl HLA-DRB5*01:01, HLA-DRB1*13:01WDR62
7603 danLISIDikndlyektl HLA-DRB1*03:01GPR98
8734 dinndiisdiSGFNSsvity HLA-DRB1*01:01GPR98
8778 diSGFNSsvitypdaqlvpg HLA-DRB1*15:01GPR98
/8903 dkisdvstivpyigPALNIvHLA-DPB1*04:01, HLA-DRB1*15:01NMDE1
9297 dltfiaeKNSFSEepfqdei HLA-DRB1*01:01, HLA-DRB1*04:01CDKL5
9595 DPALLLmheLIHVLhglygB-cell
HLA-DR2; HLA-Class II, allele undetermined		AFG32 CLN6 WDR62
9595 drLSSANlyingvlmgsaeiB-cell
HLA-DR2; HLA-Class II, allele undetermined		GPR98
10472 DTQSKnilqyikanskfigiteLKKLEski HLA-Class II, allele undeterminedSCN8A TSC1
11980 efDTQSKnilmqyikanskfigitel B-cell SCN8A
13095eLIHVLhglygmqvss B-cell
HLA-DR2; HLA-Class I, allele undetermined		WDR62
13125 eLKKLEskinkvfstpipfsHLA-Class II, allele undeterminedTSC1
13813 eqdpsgattksamltnliifgpgPVLNKNEVHLA-Class II, allele undeterminedASAH1 LRRC1
15087 eysiessmkkHSLSIGSGwsvsl B-cell PWP2 GCP6 CDKL5 RELN
15411 fdkdsnGQYIVnedkfqily HLA-Class II, allele undeterminedPWP2
16155 fiaeKNSFSEepfqdeivsyntk B-cell CDKL5
17134 fnaylankwvfiTITNDrlsHLA-Class II, allele undeterminedNHLC1
17205 fnnftVSFWLRVPKHLA-Class II, allele undeterminedGBRA1 SCN8A
17206 fnnftVSFWLRVPKVsahleHLA-DR3GBRA1 SCN8A EFHC1
17207 fnnftVSFWLRVPKVsashleHLA-DRB1*11:01, HLA-DR, HLA-DR1, HLA-DR5, HLA-DR7, HLA-DR11, HLA-DPw4, HLA-Class II, allele undeterminedGBRA1 SCN8A EFHC1
17208 fnnftVSFWLRVPKVsashleqyHLA-DRB1*01:01, HLA-DRB1*04:01, HLA-HLA-DRB1*07:01, HLA-DRB1*11:01GBRA1 SCN8A EFHC1
17487 fqilynSIMYGFTEIelgkk HLA-Class II, allele undeterminedSL9A6 SL9A9 LGI1
18217 fvksGDFIKLyvsynnnehivgy B-cell EFHC2 CNTP2
18356fwLRVPKVsashleqygtne HLA-DRB1*11:01SCN8A EFHC1
19469 gevrqiTFRDLpdkfnaylankw B-cell CLCN2
21599 gpdkeqiadeinnlknKLEEKanB-cell ARHG9
22769 gtneysiissmkkHSLSIGS DQB1*06:02, DRB5*01:01PWP2 GCP6 CDKL5
24238 hLKDKIlgcdwyfvptdegwtnd HLA-Class II, allele undeterminedROGDI
25597 idkisdvstivpyigPALNI HLA-Class II, allele undeterminedNMDE1
25666 idsfvksGDFIKLyvsynnnHLA-DRB1*15:01EFHC2 CNTP2
26808 ikiknedltfiaeKNSFSEe HLA-Class II, allele undeterminedCDKL5
27639 ingkaihlvnnesseVIVHKHLA-Class II, allele undeterminedCLN5
29241 ivdynlqskiTLPNDrttpv HLA-Class II, allele undeterminedGPR98
29331 ivkQGYEGnfigHLA-Class II, allele undeterminedTSEAR
29407 ivpyigPALNIv HLA-Class II, allele undeterminedNMDE1
29408 ivpyigPALNIvkQGYEGnf HLA-DRB1*15:01NMDE1 TSEAR
29843 KAKWLgtvntqfqKRSYQHLA-Class II, allele undeterminedLGI2 WDR62
29891 kamdieyNDMFNnftVSFWLrvpB-cell SCN9A GBRA1
30269 kdVQLKNitdymyltnapsy HLA-DRB1*01:01, HLA-DRB1*04:01GPR98
30436KEIEKlytSYLSITFLRDpwgnpB-cell CSMD3 KCMA1 GCP6 GTR1
SCN1A SCN2A SCN8A CLCN2
30572 keqiadeinnlknKLEEKanHLA-Class II, allele undeterminedARHG9
32521 knitdymyltnapsyTNGKL HLA-Class II, allele undeterminedWDR62
32546 knldcwvdneEDIDVilkkstil B-cell GABR1
33527 kstilnldinndiisdiSGFNSs B-cell GPR98
34301 kwievyKLVKAKWLgtvntqHLA-DRB1*01:01ARHGA LGI2
34887 lankwvfiTITNDrLSSANlyinB-cell NHLC1 GPR98
35058 lcikiknedltfiaeKNSFS HLA-DRB1*04:01CDKL5
35566 lekryekwievyKLVKAKWLHLA-Class II, allele undeterminedARHGA LGI2
35993 lftFGGQDanLISIDikndlHLA-Class II, allele undeterminedSCN1A SCN2A SCN8A GPR98
36667 lipvassskdVQLKNitdym HLA-DRB1*11:01GPR98
38977 lqrITMTNSVDDALinstkiHLA-Class II, allele undeterminedVP13A MK10
40770 lygmqvsshEIIPSkqeiym HLA-Class II, allele undeterminedACHA2 ACHA4
41527 mfnnftVSFWLRVPKVsashHLA-DRB1*11:01GBRA1 SCN8A EFHC1
42847 mtnSVDDALinstkiysyfpHLA-DRB1*11:01MK10
43280 napsyTNGKLniyyrrlynglkf B-cell WDR62
43519 ndrLSSANlyingvlmgsaeHLA-Class II, allele undeterminedGPR98
43591 neEDIDVilkkstilnldin HLA-Class II, allele undeterminedGABR1
43939 nftVSFWLRVPKHLA-Class II, allele undeterminedGBRA1 SCN8A
43940 nftVSFWLRVPKVsashleHLA-DRB1*11:01GBRA1 SCN8A EFHC1
44007 ngkaihlvnnesseVIVHKamdiB-cell CLN5
44396 nivkQGYEGnfi HLA-Class II, allele undeterminedTSEAR
44200 niddntiyqylyaqkSPTTL HLA-DRB1*01:01SL9A6
44383 NITSLtigkskyfqDPALLLHLA-ClassII, allele undeterminedACHA2 AFG32 CLN6
44557 NKNEVrgivlrvdnknyfpc HLA-Class II, allele undeterminedLRRC1
44667 nldinndiisdiSGFNSsvi HLA-Class II, allele undeterminedGPR98
45102 nnftVSFWLRVPKVsashleHLA-Class II, allele undeterminedGBRA1 SCN8A EFHC1
46136 ntiyqylyaqkSPTTLqrit HLA-Class II, allele undeterminedSL9A6
46853 PALLLmheLIHVLhglygmqHLA-Class II, allele undeterminedCLN6 WDR62
46855 PALNIvkQGYEGnfigalet HLA-Class II, allele undeterminedNMDE1 TSEAR
48049 PKEIEKlytSYLSITFLRDfHLA-Class II, allele undeterminedGCP6 CSMD3 KCMA1 GTR1
SCN1A SCN2A SCN8A CLCN2
48697 pnrdiliasnwyfnhLKDKIlgc B-cell ROGDI
49984 pvtkGIPYApeyksnaastteihB-cell CBPA6
51254 qkSPTTLqrITMTNSVDDALInsB-cell SL9A6 VP13A MK10
56528 ryekwievyKLVKAKWLgtvntq B-cell ARHGA LGI2
57935 sfvksGDFIKLyvsynnneh HLA-ClassII, allele undeterminedEFHC2 CNTP2
57947 sfwLRVPKVsashle HLA-DR5, HLA-DRB1*11:01SCN8A EFHC1
58527 SIGSGwsvslkgnnliwtlk HLA-DRB1*03:01RELN
59500 SLTDLggelcikikn HLA-Class II, allele undeterminedLRRC1
61214 ssmkkHSLSIGSGwsvslkg HLA-Class II, allele undeterminedPWP2 GCP6 CDKL5 RELN
61354 ssskdVQLKNitdymyltnapsy B-cell GPR98
62073 SVDDALinstkiysyfpsviskvnqGAQGIlHLA-Class II, allele undeterminedMK10
63277 tdymyltnapsyTNGKLniy HLA-DRB1*01:01, HLA-DRB1*04:01WDR62
63450 teLKKLEskinkvfstpipf HLA-DRB1*07:01TSC1
64514 tiyndtEGFNIESKDLksey HLA-Class II, allele undeterminedCSMD3 GPR98
65324 TNGKLniyyrrlynglkfii HLA-Class II, allele undeterminedWDR62
67104 tvntqfqKRSYQmyrsletqvda B-cell WDR62
67147 tVSFWLRVPKVsaHLA-DRB1*11:01, HLA-DRB1*11:04GBRA1 SCN8A EFHC1
67148 tVSFWLRVPKVsashleHLA-DRB1*11:01GBRA1 SCN8A EFHC1
68104 vdynlqskiTLPNDrttpvt HLA-DQB1*06:02GPR98
69149 VIVHKamdieyNDMFNnftvHLA-Class II, allele undeterminedCLN5 SCN9A
69180 vKAKWLgtvntqfqKRSYQm HLA-DQB1*06:02LGI2 WDR62
70202 vntqfqKRSYQmyrsleyqv HLA-DRB1*07:01WDR62
70165 vnqGAQGIlflqwvrdiiddHLA-Class II, allele undeterminedMK10
70166 vnqGAQGIlflqwvrdiiddftnB-cell MK10
70514 vpyigPALNIvk HLA-Class II, allele undeterminedNMDE1
70982 vsidkfriFCKALnpkHLA-DRB1*11:01LRRC1 SCN8A KCMA1
71155 vstivpyigPALNI HLA-DR, HLA-DR1, HLA-A*02:01NMDE1
71156 vstivpyigPALNIvkQGYEGnf B-cell NMDE1 TSEAR
72784 wLRVPKVsashleqygtneysie B-cell SCN8A EFHC1
76411 yvsidkfriFCKALnPKEIEHLA-Class II, allele undeterminedLRRC1 KCMA15
76537 yylipvassskdVQLKNitd HLA-Class II, allele undeterminedGPR98
79808 eLIHVLhglygmq HLA-DRA*01:01, HLA-DRB1*01:01WDR62 KCMA1
79816 evyKLVKAKWLgt HLA-DRA*01:01, HLA-DRB1*01:01ARHGA LGI2
113407 fnnftVSFWLRVPKVsasHLA-DR11GBRA1 SCN8A EFHC1
167585 glygmqvsshEIIPSkqeiy HLA-DRB1*12:01ACHA2 ACHA4
167613 kvnqGAQGIlflqwvrdiidHLA-DRB1*12:01MK10
167626 nLISIDikndlyektlndyk HLA-DRB1*12:01GPR98
167666 shEIIPSkqeiymqhtypis HLA-DRB1*12:01ACHA2 ACHA4
One hundred and sixteen linear TT-derived epitopes that had been found to be immunopositive in the human host were analyzed. Epitope number refers to IEDB ID. Further details and references are reported in the Immune Epitope Database (IEDB; http://www.immuneepitope.org/.
Aa sequences given in one-letter code.
Peptide fragments shared with epilepsy-associated proteins in capital.
Epilepsy-associated proteins reported as UniProt/Swiss-prot entries. For details and references, see http://www.uniprot.org/.
TT-derived epitope ID 76411 shares both pentapeptides FCKAL and PKEIE with human KCMA1 (or calcium-activated potassium channel subunit alpha-1).