Table of Contents
Epilepsy Research and Treatment
Volume 2014, Article ID 404202, 6 pages
http://dx.doi.org/10.1155/2014/404202
Review Article

The Modified Atkins Diet in Refractory Epilepsy

Division of Pediatric Neurology, Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children’s Hospital, New Delhi 110001, India

Received 23 October 2013; Accepted 10 December 2013; Published 30 January 2014

Academic Editor: József Janszky

Copyright © 2014 Suvasini Sharma and Puneet Jain. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. W. A. Hauser, “The prevalence and incidence of convulsive disorders in children,” Epilepsia, vol. 35, supplement 2, pp. S1–S6, 1994. View at Google Scholar · View at Scopus
  2. J. M. Pellock, “Seizures and epilepsy in infancy and childhood,” Neurologic Clinics, vol. 11, no. 4, pp. 755–775, 1993. View at Google Scholar · View at Scopus
  3. P. N. Patsalos and J. S. Duncan, “Antiepileptic drugs. A review of clinically significant drug interactions,” Drug Safety, vol. 9, no. 3, pp. 156–184, 1993. View at Google Scholar · View at Scopus
  4. S. Shorvon, F. Dreifuss, and D. Fish, The Treatment of Epilepsy, Blackwell Science, 1996.
  5. F. J. Ritter, I. E. Leppik, F. E. Dreifuss et al., “Efficacy of felbamate in childhood epileptic encephalopathy (Lennox-Gastaut syndrome),” The New England Journal of Medicine, vol. 328, no. 1, pp. 29–33, 1993. View at Publisher · View at Google Scholar · View at Scopus
  6. R. George, M. Salinsky, R. Kuzniecky et al., “Vagus nerve stimulation for treatment of partial seizures: 3. Long-term follow-up on first 67 patients exiting a controlled study,” Epilepsia, vol. 35, no. 3, pp. 637–643, 1994. View at Publisher · View at Google Scholar · View at Scopus
  7. E. P. G. Vining, J. M. Freeman, K. Ballaban-Gil et al., “A multicenter study of the efficacy of the ketogenic diet,” Archives of Neurology, vol. 55, no. 11, pp. 1433–1437, 1998. View at Google Scholar · View at Scopus
  8. J. M. Freeman, E. P. G. Vining, D. J. Pillas, P. L. Pyzik, J. C. Casey, and M. T. Kelly, “The efficacy of the ketogenic diet—1998: a prospective evaluation of intervention in 150 children,” Pediatrics, vol. 102, no. 6, pp. 1358–1363, 1998. View at Google Scholar · View at Scopus
  9. A. M. Hassan, D. L. Keene, S. E. Whiting, P. J. Jacob, J. R. Champagne, and P. Humphreys, “Ketogenic diet in the treatment of refractory epilepsy in childhood,” Pediatric Neurology, vol. 21, no. 2, pp. 548–552, 1999. View at Publisher · View at Google Scholar · View at Scopus
  10. N. G. Katyal, A. N. Koehler, B. McGhee, C. M. Foley, and P. K. Crumrine, “The ketogenic diet in refractory epilepsy: the experience of Children's Hospital of Pittsburgh,” Clinical Pediatrics, vol. 39, no. 3, pp. 153–159, 2000. View at Google Scholar · View at Scopus
  11. P. Kankirawatana, P. Jirapinyo, S. Kankirawatana, R. Wongarn, and N. Thamanasiri, “Ketogenic diet : an alternative treatment for refractory epilepsy in children,” Journal of the Medical Association of Thailand, vol. 84, no. 7, pp. 1027–1032, 2001. View at Google Scholar · View at Scopus
  12. E. H. Kossoff, G. L. Krauss, J. R. McGrogan, and J. M. Freeman, “Efficacy of the Atkins diet as therapy for intractable epilepsy,” Neurology, vol. 61, no. 12, pp. 1789–1791, 2003. View at Google Scholar · View at Scopus
  13. E. H. Kossoff, J. R. McGrogan, R. M. Bluml, D. J. Pillas, J. E. Rubenstein, and E. P. Vining, “A modified Atkins diet is effective for the treatment of intractable pediatric epilepsy,” Epilepsia, vol. 47, no. 2, pp. 421–424, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. H.-C. Kang, H. S. Lee, S. J. You, D. C. Kang, T.-S. Ko, and H. D. Kim, “Use of a modified Atkins diet in intractable childhood epilepsy,” Epilepsia, vol. 48, no. 1, pp. 182–186, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. E. H. Kossoff and J. L. Dorward, “The modified Atkins diet,” Epilepsia, vol. 49, supplement 8, pp. 37–41, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. E. H. Kossoff, “More fat and fewer seizures: dietary therapies for epilepsy,” The Lancet Neurology, vol. 3, no. 7, pp. 415–420, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Atkins, Dr. Atkins’ New Diet Revolution, Harper-Collins Publishers, 2004.
  18. E. H. Kossoff, Z. Turner, R. M. Bluml, P. L. Pyzik, and E. P. G. Vining, “A randomized, crossover comparison of daily carbohydrate limits using the modified Atkins diet,” Epilepsy and Behavior, vol. 10, no. 3, pp. 432–436, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. N. Porta, L. Vallée, E. Boutry et al., “Comparison of seizure reduction and serum fatty acid levels after receiving the ketogenic and modified Atkins diet,” Seizure, vol. 18, no. 5, pp. 359–364, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. S. Weber, C. Mølgaard, K. KarenTaudorf, and P. Uldall, “Modified Atkins diet to children and adolescents with medical intractable epilepsy,” Seizure, vol. 18, no. 4, pp. 237–240, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. S. H. Tonekaboni, P. Mostaghimi, P. Mirmiran et al., “Efficacy of the atkins diet as therapy for intractable epilepsy in children,” Archives of Iranian Medicine, vol. 13, no. 6, pp. 492–497, 2010. View at Google Scholar · View at Scopus
  22. M. J. Miranda, M. Mortensen, J. H. Povlsen, H. Nielsen, and S. Beniczky, “Danish study of a modified Atkins diet for medically intractable epilepsy in children: can we achieve the same results as with the classical ketogenic diet?” Seizure, vol. 20, no. 2, pp. 151–155, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. E. H. Kossoff, J. L. Dorward, Z. Turner, and P. L. Pyzik, “Prospective study of the modified atkins diet in combination with a ketogenic liquid supplement during the initial month,” Journal of Child Neurology, vol. 26, no. 2, pp. 147–151, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. L. B. Groomes, P. L. Pyzik, Z. Turner, J. L. Dorward, V. H. Goode, and E. H. Kossoff, “Do patients with absence epilepsy respond to ketogenic diets?” Journal of Child Neurology, vol. 26, no. 2, pp. 160–165, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. T. Kumada, T. Miyajima, N. Oda, H. Shimomura, K. Saito, and T. Fujii, “Efficacy and tolerability of modified Atkins diet in Japanese children with medication-resistant epilepsy,” Brain & Development, vol. 34, no. 1, pp. 32–38, 2012. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Sharma, N. Sankhyan, S. Gulati, and A. Agarwala, “Use of the modified Atkins diet in infantile spasms refractory to first-line treatment,” Seizure, vol. 21, no. 1, pp. 45–48, 2012. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. M. Kim, V. V. Vaidya, T. Khusainov et al., “Various indications for a modified Atkins diet in intractable childhood epilepsy,” Brain & Development, vol. 34, pp. 570–575, 2012. View at Google Scholar
  28. S. Sharma, N. Sankhyan, S. Gulati, and A. Agarwala, “Use of the modified Atkins diet for treatment of refractory childhood epilepsy: a randomized controlled trial,” Epilepsia, vol. 54, pp. 481–486, 2013. View at Google Scholar
  29. N. E. Payne, J. H. Cross, J. W. Sander, and S. M. Sisodiya, “The ketogenic and related diets in adolescents and adults—a review,” Epilepsia, vol. 52, no. 11, pp. 1941–1948, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. E. H. Kossoff, H. Rowley, S. R. Sinha, and E. P. G. Vining, “A prospective study of the modified Atkins diet for intractable epilepsy in adults,” Epilepsia, vol. 49, no. 2, pp. 316–319, 2008. View at Publisher · View at Google Scholar · View at Scopus
  31. E. Carrette, K. Vonck, V. de Herdt et al., “A pilot trial with modified Atkins' diet in adult patients with refractory epilepsy,” Clinical Neurology and Neurosurgery, vol. 110, no. 8, pp. 797–803, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. E. H. Kossoff, J. L. Borsage, and A. M. Comi, “A pilot study of the modified Atkins diet for Sturge-Weber syndrome,” Epilepsy Research, vol. 92, no. 2-3, pp. 240–243, 2010. View at Publisher · View at Google Scholar · View at Scopus
  33. M. Smith, N. Politzer, D. MacGarvie, M.-P. McAndrews, and M. Del Campo, “Efficacy and tolerability of the modified Atkins diet in adults with pharmacoresistant epilepsy: a prospective observational study,” Epilepsia, vol. 52, no. 4, pp. 775–780, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. W. Chen and E. H. Kossoff, “Long-term follow-up of children treated with the modified Atkins diet,” Journal of Child Neurology, vol. 27, pp. 754–758, 2012. View at Google Scholar
  35. E. H. Kossoff, J. L. Dorward, M. R. Molinero, and K. R. Holden, “The modified Atkins diet: a potential treatment for developing countries,” Epilepsia, vol. 49, no. 9, pp. 1646–1647, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. E. H. Kossoff, J. L. Bosarge, M. J. Miranda, A. Wiemer-Kruel, H. C. Kang, and H. D. Kim, “Will seizure control improve by switching from the modified Atkins diet to the traditional ketogenic diet?” Epilepsia, vol. 51, no. 12, pp. 2496–2499, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. Y. Ito, H. Oguni, S. Ito, M. Oguni, and M. Osawa, “A modified Atkins diet is promising as a treatment for glucose transporter type 1 deficiency syndrome,” Developmental Medicine and Child Neurology, vol. 53, no. 7, pp. 658–663, 2011. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Kumada, T. Miyajima, N. Kimura et al., “Modified atkins diet for the treatment of nonconvulsive status epilepticus in children,” Journal of Child Neurology, vol. 25, no. 4, pp. 485–489, 2010. View at Publisher · View at Google Scholar · View at Scopus
  39. E. H. Kossoff, J. Huffman, Z. Turner, and J. Gladstein, “Use of the modified Atkins diet for adolescents with chronic daily headache,” Cephalalgia, vol. 30, no. 8, pp. 1014–1016, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. P. O. Kwiterovich Jr., E. P. G. Vining, P. Pyzik, R. Skolasky Jr., and J. M. Freeman, “Effect of a high-fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children,” Journal of the American Medical Association, vol. 290, no. 7, pp. 912–920, 2003. View at Publisher · View at Google Scholar · View at Scopus