Both Maternal and Pup Genotype Influence Ultrasonic Vocalizations and Early Developmental Milestones in Tsc2^+/− Mice

Figure 5

WT and Tsc2 heterozygous pups born to WT mothers display delayed development for certain milestones. (a) WT and heterozygous pups have no differences in weight. (b) Tsc2 heterozygous pups from WT mothers display delayed righting reflex compared to WT pups at pnd 4. (c) Heterozygous pups have delayed geotaxis at pnds 7 and 9 as compared to WT pups. (d) WT and heterozygous pups show no significant differences in forelimb grasp. (e) WT and heterozygous pups show no significant differences in level screen test. (f) WT and heterozygous pups show no significant differences in cliff aversion. (g) Heterozygous pups have impaired bar hang as compared to WT pups at pnds 7 and 8. (h) WT and heterozygous pups have no significant differences in auditory startle response. ^∗𝑃<0.05; ^∗∗𝑃<0.005.

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