Table of Contents
Epilepsy Research and Treatment
Volume 2016, Article ID 7417540, 7 pages
http://dx.doi.org/10.1155/2016/7417540
Research Article

Cerebral Hemispheric Lateralization Associated with Hippocampal Sclerosis May Affect Interictal Cardiovascular Autonomic Functions in Temporal Lobe Epilepsy

1Physiology Laboratory, Faculty of Medicine and Pharmacy, Mohammed V-Souissi University, 6203 Rabat, Morocco
2Department of Clinical Neurophysiology, Hospital of Specialties, Ibn Sina University Hospital, Rabat Institute, 6220 Rabat, Morocco
3Unit of Cardiology A, Ibn Sina University Hospital, 10000 Rabat, Morocco
4Food Sciences Laboratory, Department of Biology, Faculty of Sciences Semlalia, Prince Moulay Abdellah Avenue, 40090 Marrakesh, Morocco

Received 25 October 2015; Revised 11 January 2016; Accepted 26 January 2016

Academic Editor: Louis Lemieux

Copyright © 2016 Rokia Ghchime et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It is well established that the temporal lobe epilepsy (TLE) is linked to the autonomic nervous system dysfunctions. Seizures alter the function of different systems such as the respiratory, cardiovascular, gastrointestinal, and urogenital systems. The aim of this work was to evaluate the possible factors which may be involved in interictal cardiovascular autonomic function in temporal lobe epilepsy with complex partial seizures, and with particular attention to hippocampal sclerosis. The study was conducted in 30 patients with intractable temporal lobe epilepsy (19 with left hippocampal sclerosis, 11 with right hippocampal sclerosis). All subjects underwent four tests of cardiac autonomic function: heart rate changes in response to deep breathing, heart rate, and blood pressure variations throughout resting activity and during hand grip, mental stress, and orthostatic tests. Our results show that the right cerebral hemisphere predominantly modulates sympathetic activity, while the left cerebral hemisphere mainly modulates parasympathetic activity, which mediated tachycardia and excessive bradycardia counterregulation, both of which might be involved as a mechanism of sudden unexpected death in epilepsy patients (SUDEP).