Review Article
Cytogenetics and Molecular Genetics of Myxoid Soft-Tissue Sarcomas
Table 1
Chromosomal alterations and related molecular events in myxoid soft-tissue sarcomas.
| | Tumor type | Chromosomal alteration | Molecular event | Prevalence |
| | Myxoid/round cell liposarcoma | t(12; 16)(q13; p11) | FUS-DDIT3 | >90% | | t(12; 22)(q13; q12) | EWSR1-DDIT3 | <5% | | Low-grade fibromyxoid sarcoma | t(7; 16)(q32–34; p11) | FUS-CREB3L2 | >95% | | t(11; 16)(p11; p11) | FUS-CREB3L1 | <5% | | Extraskeletal myxoid chondrosarcoma | t(9; 22)(q22; q12) | EWSR1-NR4A3 | 75% | | t(9; 17)(q22; q11) | TAF15-NR4A3 | 15% | | t(9; 15)(q22; q21) | TCF12-NR4A3 | <1% | | t(3; 9)(q12; q22) | TFG-NR4A3 | <1% | | Myxofibrosarcoma | Complex karyotype | Not known | Not applicable | | Myxoinflammatory fibroblastic sarcoma | t(1; 10)(p22; q24) | Deregulation of FGF8 and NPM3 | Not applicable | | Rearrangement of TGFBR3 and MGEA5 | Not applicable | | Myxoid dermatofibrosarcoma protuberans | t(17; 22)(q22; q13)* | COL1A1-PDGFB | >90% |
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*Rearrangement also frequently seen as a ring chromosome.
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