Research Article

Integrated Genomic Analysis of Sézary Syndrome

Table 2

A detailed gene list of the 3 LOH gene clusters separating SS from NC

LOH gene clustersGene nameCommonDescription

9q31q34221294_atGPR21G-protein-coupled receptor 21
221085_atTNFSF15Tumor necrosis factor (ligand) superfamily, member 15
220935_s_atCDK5RAP2CDK5 regulatory subunit associated protein 2
220300_atRGS3Regulator of G-protein signalling 3
220202_s_atMNABMembrane-associated nucleic acid binding protein
220201_atMNABMembrane-associated nucleic acid binding protein
219884_atLHX6LIM homeobox protein 6
218941_atFBXW2F-box and WD-40 domain protein 2
218489_s_atALADAminolevulinate, delta-, dehydratase
218487_atALADAminolevulinate, delta-, dehydratase
218160_atNDUFA8NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19 kDa
215813_s_atPTGS1Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
214465_atORM2Orosomucoid 2
214425_atAMBPAlpha-1-microglobulin/bikunin precursor
214040_s_atGSNGelsolin (amyloidosis, Finnish type)
211503_s_atRAB14RAB14, member RAS oncogene family
210825_s_atSTOMStomatin
210824_atSTOMStomatin
209162_s_atPRPF4PRP4 pre-mRNA processing factor 4 homolog (yeast)
209161_atPRPF4PRP4 pre-mRNA processing factor 4 homolog (yeast)
208828_atPOLE3Polymerase (DNA directed), epsilon 3 (p17 subunit)
208737_atATP6V1G1ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G isoform 1
205599_atTRAF1TNF receptor-associated factor 1
205500_atC5Complement component 5
205477_s_atAMBPAlpha-1-microglobulin/bikunin precursor
205128_x_atPTGS1Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
205127_atPTGS1Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
205041_s_atORM1Orosomucoid 1
205040_atORM1Orosomucoid 1
204449_atPDCLPhosducin-like
204448_s_atPDCLPhosducin-like
203971_atSLC31A1Solute carrier family 31 (copper transporters), member 1
203823_atRGS3Regulator of G-protein signalling 3
203447_atPSMD5Proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
201062_atSTOMStomatin
201061_s_atSTOMStomatin
201060_x_atSTOMStomatin
200928_s_atRAB14RAB14, member RAS oncogene family
200927_s_atRAB14RAB14, member RAS oncogene family
200696_s_atGSNGelsolin (amyloidosis, Finnish type)

10p11.21q26.332094_atCHST3Carbohydrate (chondroitin 6) sulfotransferase 3
222072_atADD3Homo sapiens clone DT1P1A11 mRNA, CAG repeat region
221136_atGDF2Growth differentiation factor 2
219963_atDUSP13Dual specificity phosphatase 13
219957_atRUFY2RUN and FYVE domain containing 2
219543_atMAWBPMAWD binding protein
219509_atMYOZ1Myozenin 1
218878_s_atSIRT1Sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)
218871_x_atGALNACT-2Chondroitin sulfate GalNAcT-2
218445_atH2AFY2H2A histone family, member Y2
218249_atZDHHC6Zinc finger, DHHC domain containing 6
218046_s_atMRPS16Mitochondrial ribosomal protein S16
218006_s_atZNF22Zinc finger protein 22 (KOX 15)
218005_atZNF22Zinc finger protein 22 (KOX 15)
216903_s_atCBARA1Calcium binding atopy-related autoantigen 1
216345_atKIAA0913KIAA0913 protein
216037_x_atTCF7L2Transcription factor 7-like 2 (T-cell specific, HMG-box)
216035_x_atTCF7L2Transcription factor 7-like 2 (T-cell specific, HMG-box)
214878_atZNF37AZinc finger protein 37a (KOX 21)
214617_atPRF1Perforin 1 (pore forming protein)
214508_x_atCREMcAMP responsive element modulator
214366_s_atALOX5Arachidonate 5-lipoxygenase
214348_atTACR2Tachykinin receptor 2
214338_atDNAJB12DnaJ (Hsp40) homolog, subfamily B, member 12
214322_atCAMK2GCalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
214136_atNUDT13Nudix (nucleoside diphosphate linked moiety X)-type motif 13
213952_s_atALOX5Arachidonate 5-lipoxygenase
213647_atDNA2LDNA2 DNA replication helicase 2-like (yeast)
212894_atSUPV3L1Suppressor of var1, 3-like 1 (S. cerevisiae)
212762_s_atTCF7L2Transcription factor 7-like 2 (T-cell specific, HMG-box)
212761_atTCF7L2Transcription factor 7-like 2 (T-cell specific, HMG-box)
212759_s_atTCF7L2Transcription factor 7-like 2 (T-cell specific, HMG-box)
212757_s_atCAMK2GCalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
212669_atCAMK2GCalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
212594_atPDCD4Programmed cell death 4 (neoplastic transformation inhibitor)
212593_s_atPDCD4Programmed cell death 4 (neoplastic transformation inhibitor)
212359_s_atKIAA0913KIAA0913 protein
212322_atSGPL1Sphingosine-1-phosphate lyase 1
212321_atSGPL1Sphingosine-1-phosphate lyase 1
211809_x_atCOL13A1Collagen, type XIII, alpha 1
211668_s_atPLAUplasminogen activator, urokinase
211343_s_atCOL13A1Collagen, type XIII, alpha 1
210956_atPPYR1Pancreatic polypeptide receptor 1
210671_x_atMAPK8Mitogen-activated protein kinase 8
210588_x_atHNRPH3Heterogeneous nuclear ribonucleoprotein H3 (2H9)
210477_x_atMAPK8Mitogen-activated protein kinase 8
210318_atRBP3Retinol binding protein 3, interstitial
210171_s_atCREMcAMP responsive element modulator
210110_x_atHNRPH3Heterogeneous nuclear ribonucleoprotein H3 (2H9)
209910_atSLC25A16Solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16
209869_atADRA2AAdrenergic, alpha-2A-, receptor
209860_s_atANXA7Annexin A7
209834_atCHST3Carbohydrate (chondroitin 6) sulfotransferase 3
209817_atPPP3CBProtein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)
209538_atZNF32Zinc finger protein 32 (KOX 30)
209457_atDUSP5Dual specificity phosphatase 5
209045_atXPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
208990_s_atHNRPH3Heterogeneous nuclear ribonucleoprotein H3 (2H9)
208770_s_atEIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2
208769_atEIF4EBP2Eukaryotic translation initiation factor 4E binding protein 2
208535_x_atCOL13A1Collagen, type XIII, alpha 1
208453_s_atXPNPEP1X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
208381_s_atSGPL1Sphingosine-1-phosphate lyase 1
208252_s_atCHST3Carbohydrate (chondroitin 6) sulfotransferase 3
208152_s_atDDX21DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 21
208095_s_atCAMK2GCalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
207965_atNEUROG3Neurogenin 3
207630_s_atCREMcAMP responsive element modulator
207543_s_atP4HA1Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I
207347_atERCC6Excision repair cross-complementing rodent repair deficiency, complementation group 6
207127_s_atHNRPH3Heterogeneous nuclear ribonucleoprotein H3 (2H9)
206747_atKIAA0514KIAA0514 gene product
206261_atZNF239Zinc finger protein 239
206159_atGDF10Growth differentiation factor 10
206010_atHABP2Hyaluronan binding protein 2
205882_x_atADD3Adducin 3 (gamma)
205879_x_atRETRet proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)
205479_s_atPLAUPlasminogen activator, urokinase
204446_s_atALOX5Arachidonate 5-lipoxygenase
204445_s_atALOX5Arachidonate 5-lipoxygenase
204120_s_atADKAdenosine kinase
204119_s_atADKAdenosine kinase
203916_atNDST2N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2
203666_atCXCL12Chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1)
203187_atDOCK1Dedicator of cyto-kinesis 1
203079_s_atCUL2Cullin 2
203078_atCUL2Cullin 2
203074_atANXA8Annexin A8
202867_s_atDNAJB12DnaJ (Hsp40) homolog, subfamily B, member 12
202866_atDNAJB12DnaJ (Hsp40) homolog, subfamily B, member 12
202865_atDNAJB12DnaJ (Hsp40) homolog, subfamily B, member 12
202777_atSHOC2soc-2 suppressor of clear homolog (C. elegans)
202731_atPDCD4Programmed cell death 4 (neoplastic transformation inhibitor)
202730_s_atPDCD4Programmed cell death 4 (neoplastic transformation inhibitor)
202524_s_atSPOCK2Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
202523_s_atSPOCK2Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
202432_atPPP3CBProtein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)
202364_atMXI1MAX interacting protein 1
202361_atSEC24CSEC24 related gene family, member C (S. cerevisiae)
201859_atPRG1Proteoglycan 1, secretory granule
201858_s_atPRG1Proteoglycan 1, secretory granule
201753_s_atADD3Adducin 3 (gamma)
201752_s_atADD3Adducin 3 (gamma)
201376_s_atHNRPFHeterogeneous nuclear ribonucleoprotein F
201366_atANXA7Annexin A7
201034_atADD3Adducin 3 (gamma)
200931_s_atVCLVinculin
200930_s_atVCLVinculin
200871_s_atPSAPProsaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
200866_s_atPSAPProsaposin (variant Gaucher disease and variant metachromatic leukodystrophy)
200697_atHK1Hexokinase 1

13q11q1236830_atMIPEPMitochondrial intermediate peptidase
221995_s_atMRP63Mitochondrial ribosomal protein 63
221771_s_atHSMPP8M-phase phosphoprotein, mpp8
220753_s_atCRYL1Crystallin, lambda 1
218479_s_atXPO4Exportin 4
213262_atSACSSpastic ataxia of Charlevoix-Saguenay (sacsin)
208742_s_atSAP18sin3-associated polypeptide, 18 kDa
208741_atSAP18sin3-associated polypeptide, 18 kDa
208740_atSAP18sin3-associated polypeptide, 18 kDa
208590_x_atGJA3Gap junction protein, alpha 3, 46 kDa (connexin 46)
207302_atSGCGSarcoglycan, gamma (35 kDa dystrophin-associated glycoprotein)
206404_atFGF9Fibroblast growth factor 9 (glia-activating factor)
204387_x_atMRP63Mitochondrial ribosomal protein 63
204386_s_atMRP63Mitochondrial ribosomal protein 63
204305_atMIPEPMitochondrial intermediate peptidase