Genetics Research International / 2012 / Article / Fig 1

Review Article

Finding a Balance: How Diverse Dosage Compensation Strategies Modify Histone H4 to Regulate Transcription

Figure 1

X chromosome dosage compensation. Dosage compensation balances expression of the X chromosomes between males and females and equalizes expression between the X and autosomes. In male flies, the single X chromosome is upregulated. C. elegans upregulates the X chromosomes in hermaphrodites and males, and the dosage compensation complex functions in hermaphrodites to downregulate transcription two-fold. The X chromosomes are upregulated in female and male mammals, but one X chromosome is inactivated in females. Green text indicates upregulation, and red text indicates downregulation. Yellow boxes depict chromosomes that are targeted by specific dosage compensation mechanisms.

We are committed to sharing findings related to COVID-19 as quickly as possible. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. Review articles are excluded from this waiver policy. Sign up here as a reviewer to help fast-track new submissions.