Review Article

DNA Methylation Pattern as Important Epigenetic Criterion in Cancer

Table 1

Gene silencing proteins and diseases [78].

ProteinCellular defect/disease

DNMT1Developmental
abnormalities
Igf2 imprinting
Colon cancer
Lymphoma
Pancreatic cancer

DNMT3BDevelopmental
abnormalities
ICF
Bladder cancer
Breast cancer
Colon cancer
Hepatocellular
carcinoma
Lung cancer

MeCP2Chromosome
instability/cell cycle
defects
Breast cancer
Rett syndrome

EZH2Cell cycle defects
Barrett’s esophagus
Bladder cancer
Breast cancer
Colorectal cancer
Melanoma
Myeloma/lymphoma
Hepatocellular
carcinoma
Prostate cancer
Wilms tumor

Suv39h1Blood cell defects (RBC and WBC)
Chromosome instability
Chromosome instability/cell cycle defects

HP1Breast cancer
Medulloblastoma
Papillary thyroid
carcinoma
Viral latency