Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet’s Disease

<table>Current view of helper T (Th) cell subsets in humans [<a href="/journals/gri/2013/363859/#B12">12</a>]. Naïve Th cells differentiate into several Th cell subsets in the presence of appropriate cytokines. In response to the cytokines, the corresponding signaling molecules and transcription factors are expressed to regulate lineage commitments. Th1 and Th17 cells require IL-12 and IL-23 for their expansion, respectively. TGF<i>β</i>: transforming growth factor <i>β</i>, STAT: signal transducer and activator of transcription 3, GATA: GATA transcription factor, RORC: retinoic-acid-receptor-related orphan receptor c, and Foxp3: forkhead box P3.</table>

Genetics Research International

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Figure 1: Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet’s Disease 

Figure 1 | Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet’s Disease 