Skewed Helper T-Cell Responses to IL-12 Family Cytokines Produced by Antigen-Presenting Cells and the Genetic Background in Behcet’s Disease

Table 1

TLR and corresponding PAMP and DAMP [46, 50].

TLR	PAMP	DAMP
TLR1	Bacterial lipopeptide
TLR2	HSP (mycobacteria, Chlamydia), LPS, bacterial lipopeptide, peptidoglycan	HSP, HMGB1, and lipoprotein
TLR3	Viral RNA	Self-RNA
TLR4	HSP (mycobacteria, Chlamydia), LPS	HSP60, HSP70, HMGB1, and lipoprotein
TLR6	Bacterial lipopeptide
TLR7	Viral and bacterial RNA	Chromatin and ribonucleoprotein, self-DNA
TLR9	Viral, bacterial and parasitic DNA	HSP, chromatin and ribonucleoprotein, and self-DNA

TLR: Toll-like receptors; DAMP: damage-associated molecular patterns; PAMP: pathogen-associated molecular patterns; HSP: heat shock proteins; HMGB1: high-mobility group box1; LPS: lipopolysaccharide.