Regression Modeling and Meta-Analysis of Diagnostic Accuracy of SNP-Based Pathogenicity Detection Tools for UGT1A1 Gene Mutation

Table 3

Area under curve for all the selected SNP-based pathogenicity detection tools.

		Area under the curve
Tools	Area	Std. error	P value	95% Confidence Interval
Model	.639	.071	.046	.499	.778
SIFT	.527	.075	.716	.380	.675
PolyPhen2	.516	.076	.829	.367	.666
PHD-SNP	.571	.074	.345	.426	.716
Provean	.587	.074	.249	.442	.732
Fathmm	.560	.075	.427	.413	.707
Mutpred	.580	.075	.288	.433	.727

∗Significant, 𝑃<.05.