Genetics Research International / 2014 / Article / Tab 2

Research Article

Power Estimation for Gene-Longevity Association Analysis Using Concordant Twins

Table 2

Power estimates for dominant effects using longevity concordant MZ twins.

Relative risk90+95+
100200300500800100200300500800

MAF = 0.05
 0.50.93 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.45 0.73 0.89 0.98 1.00 0.91 1.00 1.00 1.00 1.00
 0.80.21 0.38 0.51 0.72 0.90 0.53 0.81 0.94 0.99 1.00
 0.850.14 0.22 0.30 0.46 0.64 0.30 0.51 0.69 0.90 0.98
 0.90.08 0.12 0.15 0.23 0.32 0.16 0.23 0.36 0.56 0.71
 0.950.06 0.07 0.07 0.09 0.12 0.07 0.09 0.12 0.15 0.22
MAF = 0.1
 0.51.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.67 0.93 0.99 1.00 1.00 0.99 1.00 1.00 1.00 1.00
 0.80.34 0.57 0.74 0.93 0.99 0.74 0.96 0.99 1.00 1.00
 0.850.19 0.33 0.46 0.70 0.88 0.47 0.76 0.89 0.99 1.00
 0.90.11 0.17 0.24 0.34 0.50 0.22 0.38 0.51 0.75 0.93
 0.950.06 0.08 0.09 0.11 0.16 0.07 0.12 0.17 0.26 0.35
MAF = 0.2
 0.51.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.84 0.98 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.80.46 0.74 0.90 0.99 1.00 0.85 0.99 1.00 1.00 1.00
 0.850.27 0.48 0.62 0.85 0.97 0.61 0.89 0.97 1.00 1.00
 0.90.14 0.22 0.32 0.49 0.68 0.32 0.51 0.69 0.89 0.97
 0.950.08 0.09 0.11 0.15 0.22 0.10 0.16 0.22 0.33 0.46
MAF = 0.5
 0.51.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.76 0.96 1.00 1.00 1.00 0.98 1.00 1.00 1.00 1.00
 0.80.38 0.64 0.83 0.97 1.00 0.74 0.95 0.99 1.00 1.00
 0.850.23 0.41 0.56 0.78 0.93 0.48 0.75 0.91 0.99 1.00
 0.90.11 0.19 0.28 0.43 0.61 0.25 0.43 0.58 0.81 0.94
 0.950.06 0.08 0.10 0.13 0.18 0.10 0.13 0.18 0.32 0.42

Power estimates over the lines are acceptable.