Genetics Research International / 2014 / Article / Tab 4

Research Article

Power Estimation for Gene-Longevity Association Analysis Using Concordant Twins

Table 4

Power estimates for additive effects using longevity concordant DZ twins.

Relative risk90+95+
10020030050080015001002003005008001500

MAF = 0.05
 0.50.73 0.94 0.98 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.30 0.53 0.71 0.87 0.97 1.00 0.74 0.95 0.99 1.00 1.00 1.00
 0.80.16 0.23 0.34 0.51 0.72 0.92 0.34 0.56 0.73 0.93 0.99 1.00
 0.850.10 0.16 0.17 0.31 0.44 0.69 0.20 0.34 0.47 0.70 0.89 0.99
 0.90.07 0.08 0.12 0.14 0.24 0.37 0.12 0.19 0.25 0.37 0.50 0.77
 0.950.06 0.05 0.06 0.08 0.09 0.11 0.08 0.08 0.08 0.11 0.14 0.24
MAF = 0.1
 0.50.92 0.99 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.50 0.74 0.90 0.99 1.00 1.00 0.93 0.99 1.00 1.00 1.00 1.00
 0.80.25 0.44 0.54 0.76 0.92 0.99 0.57 0.83 0.95 1.00 1.00 1.00
 0.850.15 0.24 0.32 0.48 0.68 0.90 0.32 0.56 0.74 0.92 0.99 1.00
 0.90.09 0.13 0.17 0.26 0.35 0.64 0.16 0.28 0.36 0.55 0.75 0.96
 0.950.06 0.06 0.07 0.09 0.12 0.19 0.06 0.11 0.13 0.16 0.26 0.43
MAF = 0.2
 0.50.97 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.68 0.93 0.99 1.00 1.00 1.00 0.99 1.00 1.00 1.00 1.00 1.00
 0.80.36 0.63 0.79 0.94 0.99 1.00 0.78 0.98 1.00 1.00 1.00 1.00
 0.850.24 0.35 0.53 0.75 0.92 1.00 0.51 0.81 0.94 0.99 1.00 1.00
 0.90.12 0.21 0.29 0.39 0.59 0.84 0.23 0.45 0.61 0.80 0.94 1.00
 0.950.06 0.08 0.12 0.13 0.19 0.31 0.09 0.14 0.17 0.25 0.44 0.68
MAF = 0.5
 0.51.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.70.84 0.98 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
 0.80.48 0.79 0.91 0.99 1.00 1.00 0.88 1.00 1.00 1.00 1.00 1.00
 0.850.30 0.55 0.71 0.88 0.98 1.00 0.67 0.90 0.98 1.00 1.00 1.00
 0.90.16 0.25 0.38 0.57 0.72 0.95 0.33 0.56 0.74 0.92 0.99 1.00
 0.950.08 0.09 0.12 0.18 0.25 0.41 0.12 0.18 0.26 0.40 0.58 0.83

Power estimates over the lines are acceptable.