Generalized Portrait of Cancer Metabolic Pathways Inferred from a List of Genes Overexpressed in Cancer

Table 1

Examples of genes overexpressed in cancer: ten genes with the largest number of EST libraries.

Gene	Number of cancer ESTs	Number of cancer EST libraries	Number of normal ESTs	Number of normal EST libraries	Gene description
EEF1A1	26747	380	54872	1436	Translation elongation factor
GAPDH	11388	300	9446	858	Glyceraldehyde-3-phosphate dehydrogenase
ACTG1	9831	295	8826	879	Actin gamma
FTH1	5264	260	6627	758	Ferritin, heavy polypeptide 1
EEF1G	6575	255	7185	783	Eukaryotic translation elongation factor 1 gamma
RPLP0	6583	253	6400	683	Ribosomal protein, large subunit, P0
HSP90AB1	4035	253	7178	801	Heat shock protein 90 kDa alpha (cytosolic), class B member 1
PKM2	4794	248	7593	760	Pyruvate kinase, muscle
FTL	4495	246	7784	599	Ferritin, light polypeptide
RPL3	6278	242	7463	753	Ribosomal protein L3

The complete list of genes overexpressed in cancer is shown in Supplementary Table S1 (also available at ftp://ftp.ncbi.nlm.nih.gov/pub/managdav/paper_suppl/est_cancer_pathways/).