Frequency Distribution of Mannose Binding Lectin-2 and Vitamin D Receptor Gene Variants: Putative Markers for Tuberculosis

Table 3

The allele and genotype frequencies of MBL-2 polymorphism among the disease-free healthy subjects in Indian population.

Polymorphism	Genotype frequency (%)			Allele frequency
rs11003125 (H/L)	HH	HL	LL	H	L
	9 (9.6)	43 (45.7)	42 (44.7)	0.32	0.68
rs7096206 (Y/X)	YY	YX	XX	Y	X
	42 (44.7)	44 (46.8)	8 (8.7)	0.68	0.32
rs7095891 (P/Q)	PP	PQ	QQ	P	Q
	55 (58.5)	36 (38.3)	3 (3.2)	0.78	0.22
rs5030737 (A/D)	AA	AD	DD	A	D
	85 (90.4)	7 (7.4)	2 (2.2)	0.94	0.06
rs1800450 (A/B)	AA	AB	BB	A	B
	74 (78.7)	19 (20.2)	1 ()	0.89	0.11
rs1800451 (A/C)	AA	AC	CC	A	C
	89 (94.7)	5 (5.3)	0 (0)	0.97	0.03
A/O allele	AA	AO	OO	A	O
	61 (64.9)	29 (30.9)	4 (4.2)	0.89	0.11

D, B, and C: less frequent alleles for 52-, 54-, and 57-codon polymorphism, respectively
L, X, and Q: less frequent alleles of −550, −221, and +4 polymorphism, respectively
H, Y, and P: common alleles of −550, −221, and +4 polymorphism, respectively
AA genotype represents homozygous wild genotypes for structural polymorphism
AO genotype represents heterozygous genotypes of structural polymorphism
OO genotype represents homozygous mutant genotypes of structural polymorphism as well as double heterozygous genotypes (D/B, B/C) of structural polymorphism.