Table of Contents Author Guidelines Submit a Manuscript
Genetics Research International
Volume 2015 (2015), Article ID 630296, 5 pages
Research Article

Association of Polymorphisms of Phase I Metabolizing Genes with Sister Chromatid Exchanges in Occupational Workers Exposed to Toluene Used in Paint Thinners

1Department of Biotechnology, Kurukshetra University, Kurukshetra, Haryana 136119, India
2Department of Microbiology, Kurukshetra University, Kurukshetra, Haryana 136119, India
3Department of Biochemistry, Kurukshetra University, Kurukshetra, Haryana 136119, India

Received 11 September 2015; Revised 2 November 2015; Accepted 9 November 2015

Academic Editor: Martin Kupiec

Copyright © 2015 Kanu Priya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study investigated genetic damage in paint workers mainly exposed to toluene as it is a major solvent used in paint thinners. Sister chromatid exchange (SCE) assay was used as biomarker of genotoxicity. Blood samples were collected from 30 paint workers and 30 control subjects matched with respect to age and other confounding factors except for exposure to toluene. SCE frequency was found to be significantly higher in paint workers () as compared to control individuals () (). We also investigated influence of polymorphisms of CYP2E1 and CYP1A1m2 genes on SCE frequency. Our results showed that there was significant increase in frequencies of SCE among the mutant genotypes of CYP2E1 and CYP1A1m2 as compared to wild genotypes. Our study indicated that long term exposure of toluene can increase genotoxic risk in paint workers.