Genetics Research International

Research Article

Genome-Wide Gene Expression in relation to Age in Large Laboratory Cohorts of Drosophila melanogaster

Table 6

Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways identified using GSEA of temporal gene expression as compared to day 2 in the box. The first column is the normalized enrichment score (NES), the second column is the name of the KEGG pathway, and columns represented by 9–79 are days in the box. The numbers presented in the table are the median fold changes in gene expression. Missing fold change values were replaced by zeroes. The data is ranked and the False Discovery Rate (FDR) cutoff was set at 0.10.


Sum(NES)	Name	9	16	23	30	37	44	51	58	65	72	79

3.9903	LIMONENE_AND_PINENE_DEGRADATION_00903	1.905	0	0	0	0	2.09	0	0	0	0	0
2.1169	DNA_REPLICATION_03030	0	0	0	0	0	0	0	0	0	2.117	0
1.9396	MISMATCH_REPAIR_03430	0	0	0	0	0	0	0	0	0	1.94	0
1.8761	PORPHYRIN_AND_CHLOROPHYLL_METABOLISM_00860	1.876	0	0	0	0	0	0	0	0	0	0
1.8689	PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS_00040	1.869	0	0	0	0	0	0	0	0	0	0
1.8595	BASE_EXCISION_REPAIR_03410	0	0	0	0	0	0	0	0	0	1.86	0
1.7939	GLYCOSAMINOGLYCAN_BIOSYNTHESIS_-_HEPARAN_00534	0	0	0	0	0	0	0	0	0	1.794	0
0.1672	ASCORBATE_AND_ALDARATE_METABOLISM_00053	1.971	0	0	0	−1.8	0	0	0	0	0	0
0.0946	RETINOL_METABOLISM_00830	1.871	0	0	0	−1.78	0	0	0	0	0	0
−1.7027	FATTY_ACID_BIOSYNTHESIS_00061	0	0	0	0	−1.7	0	0	0	0	0	0
−1.7171	ECM-RECEPTOR_INTERACTION_04512	0	0	0	0	0	0	0	0	0	−1.72	0
−1.7337	GLYCOLYSIS_/_GLUCONEOGENESIS_00010	0	0	0	0	0	0	0	0	−1.73	0	0
−1.741	OTHER_GLYCAN_DEGRADATION_00511	0	0	0	−1.74	0	0	0	0	0	0	0
−1.7658	FOLATE_BIOSYNTHESIS_00790	0	0	0	0	0	0	0	0	0	−1.77	0
−1.7669	ALANINE_ASPARTATE_AND_GLUTAMATE_METABOL_00250	0	0	0	0	0	0	0	0	−1.77	0	0
−1.8355	NEUROACTIVE_LIGAND-RECEPTOR_INTERACTION_04080	0	0	0	0	0	0	0	0	0	0	−1.84
−3.6284	PYRUVATE_METABOLISM_00620	0	0	0	0	0	0	0	0	−1.79	−1.84	0
−3.6518	ARGININE_AND_PROLINE_METABOLISM_00330	0	0	0	0	0	0	0	0	0	−1.87	−1.78
−4.318	OXIDATIVE_PHOSPHORYLATION_00190	−1.91	0	0	0	0	0	0	0	0	−2.41	0
−6.4788	RIBOSOME_03010	−2.54	0	0	0	0	0	0	0	−1.82	−2.12	0
−9.3465	STARCH_AND_SUCROSE_METABOLISM_00500	0	0	0	−1.75	−2.04	0	0	0	−1.85	−1.82	−1.89
−9.5827	GALACTOSE_METABOLISM_00052	0	0	0	−1.92	−1.86	0	0	0	−2.08	−1.97	−1.74
−18.1624	PHOTOTRANSDUCTION_-_FLY_04745	0	−2.28	−2.21	−2.09	−2.07	0	−1.95	−2.02	−1.87	−1.9	−1.77